Robust Demographic Inference from Genomic and SNP Data

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Statistical Inference for Inverse Problems: From Sparsity-Based Methods to Neural Networks

In inverse problems, the task is to reconstruct an unknown signal from its possibly noise-corrupted measurements. Penalized-likelihood-based estimation and Bayesian estimation are two powerful statistical paradigms for the resolution of such problems. They ...

EPFL2024

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Alex Russell Lederer

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

EPFL2024

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

Impact of population size on early adaptation in rugged fitness landscapes

Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

ROYAL SOC2023

Housing, street and health: a new systemic research framework

Paola Viganò, Stéphane Joost, Dusan Licina, Anna Pagani, Valentin Daniel Maurice Bourdon, Mathias Lerch, Catarina Wall Gago, Derek Pierre Christie, Idris Guessous

As the world’s population grows in cities, urban dwellers spend a large amount of time inside their home, making housing health ever more important. Critical for residents’ health, the interactions between indoor residential environments and outdoor enviro ...

2023

IMPROVED REGULARITY OF SECOND DERIVATIVES FOR SUBHARMONIC FUNCTIONS

Xavier Fernandez-Real Girona, Riccardo Tione

In this note, we prove that if a subharmonic function Delta u >= 0 has pure second derivatives partial derivative(ii)u that are signed measures, then their negative part (partial derivative(ii)u)- belongs to L-1 (in particular, it is not singular). We then ...

Amer Mathematical Soc2023

Why computational complexity may set impenetrable barriers for epistemic reductionism

Michael Herzog, Christian Sachse, Adrien Christophe Doerig

According to physicalism, everything is physical or metaphysically connected to the physical. If physicalism were true, it seems that we should - in principle - be able to reduce the descriptions and explanations of special sciences to physical ones, for e ...

Springer2023

Analysing the potential for modal shiftbased on the logic of modal choice

Vincent Kaufmann, Eloi Antoine Maël Bernier, Florian Lucien Jacques Masse, Ludy Juliana González Villamizar

This article explores how the logic underlying modal practices tends to modulate the population’s responsiveness to improvements in global transport supply. Based on a quantitative survey conducted in 2018–2019 among the working population of the cantons o ...

2023

Maximum likelihood bolometry for ASDEX upgrade experiments

Olivier Claude Martin Février, Riccardo Rossi

Bolometry is an essential diagnostic for calculating the power balances and for the understanding of different physical aspects of tokamak experiments. The reconstruction method based on the Maximum Likelihood (ML) principle, developed initially for JET, h ...

Iop Publishing Ltd2023

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