Publications related to Mutual Information Disentangles Interactions from Changing Environments

Impact of phylogeny on structural contact inference from protein sequence data

Anne-Florence Raphaëlle Bitbol, Umberto Lupo, Nicola Dietler

Local and global inference methods have been developed to infer structural contacts from multiple sequence alignments of homologous proteins. They rely on correlations in amino acid usage at contacting sites. Because homologous proteins share a common ance ...

ROYAL SOC2023

Lattice Green's function method for Atomistic/Continuum coupling

Ankit Gupta

Metal plasticity is an inherently multiscale phenomenon due to the complex long-range field of atomistic dislocations that are the primary mechanism for plastic deformation in metals. Atomistic/Continuum (A/C) coupling methods are computationally efficient ...

EPFL2023

Mutual information in changing environments: Nonlinear interactions, out-of-equilibrium systems, and continuously varying diffusivities

Daniel Maria Busiello, Giorgio Nicoletti

Biochemistry, ecology, and neuroscience are examples of prominent fields aiming at describing interacting systems that exhibit nontrivial couplings to complex, ever-changing environments. We have recently shown that linear interactions and a switching envi ...

AMER PHYSICAL SOC2022

A Functional Perspective on Information Measures

Amedeo Roberto Esposito

Since the birth of Information Theory, researchers have defined and exploited various information measures, as well as endowed them with operational meanings. Some were born as a "solution to a problem", like Shannon's Entropy and Mutual Information. Other ...

EPFL2022

The Gray-Wyner Network and Wyner's Common Information for Gaussian Sources

Michael Christoph Gastpar, Erixhen Sula

This paper presents explicit solutions for two related non-convex information extremization problems due to Gray and Wyner in the Gaussian case. The first problem is the Gray-Wyner network subject to a sum-rate constraint on the two private links. Here, ou ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Lower-bounds on the Bayesian Risk in Estimation Procedures via f–Divergences

Michael Christoph Gastpar, Amedeo Roberto Esposito, Adrien Vandenbroucque

We consider the problem of parameter estimation in a Bayesian setting and propose a general lower-bound that includes part of the family of f-Divergences. The results are then applied to specific settings of interest and compared to other notable results i ...

2022

Correlations from structure and phylogeny combine constructively in the inference of protein partners from sequences

Anne-Florence Raphaëlle Bitbol, Nicola Dietler, Andonis Samuel Rene Gerardos

Inferring protein-protein interactions from sequences is an important task in computational biology. Recent methods based on Direct Coupling Analysis (DCA) or Mutual Information (MI) allow to find interaction partners among paralogs of two protein families ...

Public Library Science2022

Statistical limits of dictionary learning: Random matrix theory and the spectral replica method

Nicolas Macris, Jean François Emmanuel Barbier

We consider increasingly complex models of matrix denoising and dictionary learning in the Bayes-optimal setting, in the challenging regime where the matrices to infer have a rank growing linearly with the system size. This is in contrast with most existin ...

AMER PHYSICAL SOC2022

A Comparison of optimal measurement-system design with engineering judgement for bridge load testing

Ian Smith, Numa Joy Bertola

Due to conservative approaches in construction design and practice, infrastructure often has hidden reserve capacity. When quantified, this reserve has potential to improve decisions related to asset management. Field measurements, collected through load t ...

2021

Mutual information for low-rank even-order symmetric tensor estimation

Nicolas Macris, Jean François Emmanuel Barbier, Clément Dominique Luneau

We consider a statistical model for finite-rank symmetric tensor factorization and prove a single-letter variational expression for its asymptotic mutual information when the tensor is of even order. The proof applies the adaptive interpolation method orig ...

OXFORD UNIV PRESS2021