The cGAS-STING pathway as a therapeutic target in inflammatory diseases

The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS-STING activity is also linked to inflammatory disease. Here, Ablasser and colleagues discuss how cGAS-STING signalling contributes to various autoimmune, inflammatory and degenerative diseases and describe the novel therapeutics targeting this pathway.