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Bioinspired, releasable quorum sensing modulators

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Adrien Keith Lawrence, Karl Gademann
2013

Abstract

We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO2 surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.

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https://infoscience.epfl.ch/entities/publication/ff780ddd-fd0f-4bea-ab4d-ca4bcd7f2fb1

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