Laboratory of Organic Catalytic and Synthesis

The Laboratory of Organic Catalytic and Synthesis (LCSO) at EPFL focuses on discovering new reactivity in organic chemistry, particularly using catalysis. They develop non-conventional bond disconnections for synthesizing important building blocks and bioactive molecules, as well as modifying biomolecules. LCSO controls the regioselective functionalization of alkenes and alkynes using in situ tethering approaches. Their research areas include electrophilic alkynylation, transformations beyond alkynylation, modification of peptides and proteins, cyclization reactions, and in situ tethering strategies for olefins and alkynes. LCSO's work is at the forefront of modern catalysis, promoting C-C or C-X bond formation to enhance molecular complexity efficiently and rapidly.