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The Laboratory for the Study of Electrophils and the Functioning of the Genome (LEAGO) at EPFL focuses on electrophile signaling, stress response, nucleotide signaling, and genome maintenance. They have developed innovative technologies like T-REX for electrophile delivery and G-REX for profiling. LEAGO has been awarded grants from prestigious organizations like the Swiss National Science Foundation and the European Research Council. Their research delves into the precise mechanisms of electrophilic drugs and metabolites, uncovering new insights into protein functions and genome maintenance. Through a combination of in vitro studies, cell culture, and collaboration, they aim to advance the understanding of nucleotide drugs-driven protein regulation and its impact on DNA replication and genome integrity.