Publications related to Microsystems Laboratory 4

Search for the lepton flavour violating decays B0 -> emu and B0s -> emu with LHCb Run 2 data

A large variety of new physics models suggest that the rates for lepton flavour violating

b

-hadron decays may be much higher than predicted in the Standard Model, which leads to a high interest in the search for such decays. This thesis presents the sear ...

EPFL2024

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Alex Russell Lederer

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

EPFL2024

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Outman Akouissi

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

EPFL2024

Recording physiological history of cells with chemical labeling

Kai Johnsson, Julien Hiblot, Ling Hai

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

Amer Assoc Advancement Science2024

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Gioele La Manno, Alex Russell Lederer, Cheng Zhao

Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

Elsevier Sci Ltd2024

Engineering hydrogel microenvironments for epithelial organoid culture

Antonius Chrisnandy

Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

EPFL2024

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

2024

Highly dispersed nanomaterials in polymer matrix via aerosol-jet-based multi-material 3D printing

Michael James Henry Smith

Polymer-based nanocomposites emerged in the 1960s as a groundbreaking approach to advanced materials. By incorporating robust, durable, and multifunctional nanomaterials into a polymer matrix, the performance of nanocomposites has significantly surpassed t ...

Elsevier2024

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis, Marta Di Fabrizio, Domenic Burger, Carolin Böing

Multiple System Atrophy is characterized pathologically by the accumulation of alpha-synuclein (aSyn) into glial cytoplasmic inclusions (GCIs). The mechanism underlying the formation of GCIs is not well understood. In this study, correlative light and elec ...

2024

Multiscale Porosity Microfluidics to Study Bacterial Transport in Heterogeneous Chemical Landscapes

Francesco Carrara, Jiande Zhou

Microfluidic models are proving to be powerful systems to study fundamental processes in porous media, due to their ability to replicate topologically complex environments while allowing detailed, quantitative observations at the pore scale. Yet, while por ...

Hoboken2024

Microsystems Laboratory 4

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Search for the lepton flavour violating decays B0 -> emu and B0s -> emu with LHCb Run 2 data

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Recording physiological history of cells with chemical labeling

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Engineering hydrogel microenvironments for epithelial organoid culture

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Highly dispersed nanomaterials in polymer matrix via aerosol-jet-based multi-material 3D printing

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Multiscale Porosity Microfluidics to Study Bacterial Transport in Heterogeneous Chemical Landscapes

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Recording physiological history of cells with chemical labeling

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Search for the lepton flavour violating decays B0 -> emu and B0s -> emu with LHCb Run 2 data

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

Engineering hydrogel microenvironments for epithelial organoid culture

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Highly dispersed nanomaterials in polymer matrix via aerosol-jet-based multi-material 3D printing

Multiscale Porosity Microfluidics to Study Bacterial Transport in Heterogeneous Chemical Landscapes

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids