Publications related to Presidency

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Abid Oueslati

Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body formation, and neurotoxicity in vivo. However, whether phosphorylation at thes ...

2012

Parkinson's Disease: Gene Therapies

Patrick Aebischer, Bernard Schneider, Philippe Guillaume Coune

With the recent development of effective gene delivery systems, gene therapy for the central nervous system is finding novel applications. Here, we review existing viral vectors and discuss gene therapy strategies that have been proposed for Parkinson's di ...

Cold Spring Harbor Lab Press, Publications Dept2012

Gene therapy: too much splice can spoil the dish

Didier Trono

The use of integrating vectors for gene therapy - required for stable correction of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of a tumorigenic program. In this issue of the JCI, Moiani et al. and Cesana et ...

2012

Optimally Localized Wavelets and Smoothing Kernels

Kunal Narayan Chaudhury

It is well-known that the Gaussian functions and, more generally, their modulations-translations (the Gabor functions) have the unique property of being optimally localized in space and frequency in the sense of Heisenberg's uncertainty principle. In this ...

EPFL2011

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun, Philippe Guillaume Coune

Although the overabundance of human alpha-synuclein in nigral dopaminergic neurons is considered to play a pathogenic role in Parkinson's disease (PD), it remains unclear how alpha-synuclein leads to neuronal degeneration and motor symptoms. Here, we explo ...

Ios Press2011

Sampling Trajectories for Mobile Sensing

Martin Vetterli, Jayakrishnan Unnikrishnan

Classical sampling theory for sampling and reconstructing bandlimited fields in

\Re^d

addresses the problem of sampling on lattice points. We consider a generalization of this problem, in which one samples the field along

1

-dimensional spatial trajecto ...

2011

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Liliane Glauser, Darren Moore, Klodjan Stafa, Ying Liu, David Ramonet Jimenez

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical fe ...

Public Library of Science2011

Reproducing Sound Fields Using MIMO Acoustic Channel Inversion

Martin Vetterli, Mihailo Kolundzija, Christof Faller

Sound fields are essentially band-limited phenomena, both temporally and spatially. This implies that a spatially sampled sound field respecting the Nyquist criterion is effectively equivalent to its continuous original. We describe Sound Field Reconstruct ...

2011

Sensing and Recovery under Sparsity Constraints

Ali Hormati

Popular transforms, like the discrete cosine transform or the wavelet transform, owe their success to the fact that they promote sparsity. These transforms are capable of extracting the structure of a large class of signals and representing them by a few t ...

EPFL2010

Signal Processing in Space and Time

Francisco Pereira Correia Pinto

Sound waves propagate through space and time by transference of energy between the particles in the medium, which vibrate according to the oscillation patterns of the waves. These vibrations can be captured by a microphone and translated into a digital sig ...

EPFL2010

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Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Parkinson's Disease: Gene Therapies

Gene therapy: too much splice can spoil the dish

Optimally Localized Wavelets and Smoothing Kernels

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

Sampling Trajectories for Mobile Sensing

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Reproducing Sound Fields Using MIMO Acoustic Channel Inversion

Sensing and Recovery under Sparsity Constraints

Signal Processing in Space and Time

Optimally Localized Wavelets and Smoothing Kernels

Signal Processing in Space and Time

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

Gene therapy: too much splice can spoil the dish

Sampling Trajectories for Mobile Sensing

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Sensing and Recovery under Sparsity Constraints

Reproducing Sound Fields Using MIMO Acoustic Channel Inversion

Parkinson's Disease: Gene Therapies

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease