Soft Materials Laboratory

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PZE-transduced Suspended Microchannel Resonators for sensing applications

Annalisa De Pastina

This PhD thesis aims at developing a system which can measure the mechanical properties of fluidic samples in the picoliter range. The ultimate goal is the characterization of cancer cells and viscoelastic fluids (i.e. biological fluids), in order to study ...

EPFL2018

Biocompatible Amphiphilic Hydrogel–Solid Dimer Particles as Colloidal Surfactants

Esther Amstad, Jing Fan

Emulsions of two immiscible liquids can slowly coalesce over time when stabilized by surfactant molecules. Pickering emulsions stabilized by colloidal particles can be much more stable. Here, we fabricate biocompatible amphiphilic dimer particles using a h ...

2017

On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics

Philippe Renaud, Arnaud Bertsch, Mohammad Mahdi Hasani-Sadrabadi, Jules John Vandersarl, Shahin Bonakdar, Fatemeh Sadat Majedi

The use of solvent-free microfluidics to fine-tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self-assembly is driven by pH changes in a water environment, which increases biocompatibility ...

Wiley-Blackwell2014

Microfluidic chip for monitoring Ca2+ transport through a confluent layer of intestinal cells

Martinus Gijs, Paolo Silacci, Hüseyin Cumhur Tekin, Josias Basil Wacker, Christine Ruffert, Guy Vergères

The absorption of dietary calcium through the intestinal barrier is essential for maintaining health in general and especially of the bone system. We propose a microfluidic model that studies free calcium (Ca2+) transport through a confluent monolayer of C ...

Royal Soc Chemistry2014

A microfluidic process for on-chip formation of assemblies of oxide nanoparticles

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker, Danut Necula

We report the continuous growth of spherical assemblies of silica and titania nanoparticles, which were pre-activated to produce hydroxyl/ peroxy groups on their surface, by flowing a colloid-in-dioctyl phthalate emulsion into a polydimethylsiloxane microf ...

Royal Soc Chemistry2014

Hydrogel-coated microfluidic channels for cardiomyocyte culture

Déborah Heintze

The research areas of tissue engineering and drug development have displayed increased interest in organ-on-a-chip studies, in which physiologically or pathologically relevant tissues can be engineered to test pharmaceutical candidates. Microfluidic techno ...

Royal Soc Chemistry2013

From Particles to Pillars : Droplet Microfluidics Applied to the Synthesis and Assembly of Functional Metal-Oxide Nanoparticles

Josias Basil Wacker

Metal oxide nanoparticles and their applications (e.g. in nano-electronics, nano-optics or drug delivery) have seen a growing interest in the past decades. Traditional procedures to synthesize, functionalize and integrate nanoparticles in devices mostly ha ...

EPFL2012

Grafting submicron titania particles with gold nanoparticles using droplet microfluidics

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

A microfluidic method to synthesize gold–titania nanocomposites is presented. Porous TiO2 particles are first loaded with a reducing agent and then suspended in water and mixed with chloroauric acid (HAuCl4) in a droplet-by-droplet manner on a microfluidic ...

2012

Microfluidic synthesis of chitosan-based nanoparticles for fuel cell applications

Philippe Renaud, Arnaud Bertsch, Mohammad Mahdi Hasani-Sadrabadi, Mojtaba Taghipoor, Fatemeh Sadat Majedi

A microfluidic platform is developed for the synthesis of monodisperse, 100 nm, chitosan based nanoparticles using nanogelation with ATP. The resulting nanoparticles tuned and enhanced transport and electrochemical properties of Nafion based nanocomposite ...

Royal Society of Chemistry2012

From particles to pillars: on-chip synthesis of silica nanoparticle assemblies with controlled shape and size

Martinus Gijs, Virendra Kumar Parashar, Josias Basil Wacker

We describe the assembly of silica nanoparticles into superstructures with controlled shape and size. The individual nanoparticles are chemically linked to each other via silica bridges, thus providing high mechanical stability to the assembly. Key to cont ...

IEEE2011

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From Particles to Pillars : Droplet Microfluidics Applied to the Synthesis and Assembly of Functional Metal-Oxide Nanoparticles

Josias Basil Wacker

EPFL2012