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Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...
Over the course of a lifetime, the human brain acquires an astonishing amount of semantic knowledge and autobiographical memories, often with an imprinting strong enough to allow detailed information to be recalled many years after the initial learning exp ...
All functions we use in our everyday life depend on a complex interplay between both cortical and subcortical brain areas, communicating in between each others. When a region is affected by either an accident, aging or neurodegenerative diseases, the whole ...
Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...
Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...
In the present work, we approach two key aspects of memory formation: associative memory and synaptic consolidation.
The storage of associative memory is commonly related to the medial temporal lobe in humans. Experimental evidence shows that the memories ...
The formation and storage of memories has been under deep investigation for several decades. Nevertheless, the precise contribution of each brain region involved in this process and the interplay between them across memory consolidation is still largely de ...
Memory formation and storage rely on multiple interconnected brain areas, the contribution of which varies during memory consolidation. The medial prefrontal cortex, in particular the prelimbic cortex (PL), was traditionally found to be involved in remote ...
Multiple studies have found that increasing histone acetylation by means of histone deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode of action is not fully understood. In particular, it is uncle ...
Whether the attenuation of traumatic memories is mediated through the suppression of the original memory trace of fear by a new memory trace of safety, or through an updating of the original fear trace towards safety has been a long-standing question at th ...
