Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of GraphSearch.
Unit
The United of Professor Barth
LaboratoryRelated people (14)
Patrick Daniel Barth
Professor Patrick Barth is Associate Professor at EPFL and Adjunct Associate Professor at Baylor College of Medicine, Houston, TX, USA. He received training in Physics, Chemistry and Biology (University of Paris, ENS) in France and performed his PhD at the Commissiariat a l'Energie Atomique in Saclay, France on structure/function studies of membrane proteins (photosystem I) using biochemical and biophysical experimental techniques. He carried out postdoctoral studies at University of California at Berkeley with Tom Alber on computational development for calculating protein electrostatics and designing de novo selective peptide inhibitors of cellular protein interactions. He then went to the University of Washington as a postdoctoral fellow and instructor in David Baker's laboratory to develop computational techniques in the software Rosetta for predicting and designing membrane protein structures. He started his independent career and received tenure at Baylor College of Medicine. He will continue at EPFL to marry computation and experiment for understanding the molecular determinants of signal transduction, as well as modeling and designing membrane proteins with novel functions for various synthetic biology and therapeutic applications.
Robert Everett Jefferson
I am engineering GPCRs to alter their ligand binding properties, creating variants that have specific and novel signaling responses. Before working in the Barth lab, I studied membrane protein folding in James Bowie's lab at UCLA, where I probed the rather interesting folding of a chloride transporter from E. coli. Before that I employed the steric trap method (developed in the Bowie lab) to study membrane protein folding under native conditions and measured the extremely slow unfolding kinetics of the E. coli membrane enzyme diacylglycerol kinase. Before that I dabbled in membrane protein crystallography and methods to stabilize membrane proteins. Before that I was an undergraduate at Whitman College where I worked in Doug Juers lab studying the structure of myelin basic protein. Before that I was a youth of minor consequence.