Volker GassAfter completing his master’s degree in Microtechnology at the Federal Institute of Technology in Lausanne in 1989 he worked as a Project Manager at Mecanex SA, a Swiss High-Tech company active in the field of Aerospace Mechanisms. While working at Mecanex he completed a PhD in Science in the field of applied Micro-Systems Technologies at the University of Neuchâtel, Switzerland in 1994. In 1995, Volker Gass participated in the Management Buy Out of Mecanex SA. In 2000, Mecanex was acquired by the Swiss Defence and Technology group RUAG . He was appointed to lead Customer Relations and Business Development of the newly formed Systems & Space Division at RUAG Aerospace in 2004. In the same year he was appointed member of the Swiss Academy of Engineering Sciences for his contribution in the field of High-Technology Space applications. From November 2006 to June 2007, Volker Gass successfully graduated RUAG’s Top Leadership Course, and held the position of General Manager, Sales & Marketing in the Space Division of RUAG in Switzerland as well as Member of the Board of Directors (President) of Mecanex USA Inc., Berlin, CT, until December 2009.In 2008 he successfully led the acquisition of SAAB Space and its subsidiary Austrian Aerospace. From January to June 2009 Volker Gass led the business team in the successful acquisition of Oerlikon Space. From mid-2009 to September 2011 he was responsible for Special Projects in the Marketing & Sales Organization of RUAG Space Switzerland. Since October 2011, Dr. Volker Gass is nominated Director of the Swiss Space Center at the Ecole Politechnique Fédérale de Lausanne. In March 2012, he is awarded the title of Adjunct Professor at the School of Engineering (STI) of the EPFL. From January 2014 to December 2017, he was nominated member of ESA’s Human Spaceflight and Exploration Science Advisory Committee (HESAC) and from spring 2015 to December 2018, observer at ESA’s Earth Science Advisory Committee (ESAC).As of January 1, 2021, The Swiss Space Center is renamed "Space Innovation"
Devis TuiaI come from Ticino and studied in Lausanne, between UNIL and EPFL. After my PhD at UNIL in remote sensing, I was postdoc in Valencia (Spain), Boulder (CO) and EPFL, working on model adaptation and prior knowledge integration in machine learning. In 2014 I became Research Assistant Professor at University of Zurich, where I started the 'multimodal remote sensing' group. In 2017, I joined Wageningen University (NL), where I was professor of the GeoInformation Science and Remote Sensing Laboratory. Since 2020, I joined EPFL Valais, to start the ECEO lab, working at the interface between Earth observation, machine learning and environmental sciences.
Ian SmithPhD Université de Cambridge, 1982 Interêts 1 Contrôle actif de la forme des structures pour améliorer leur aptitude au service et leur déploiement 2 Structures biomimétiques (apprentissage, auto-diagnostic, auto-réparation) 3 Gestion de l'infrastructure par l'identification structurale 4 Applications avancées de l'informatique Plus de détails, voir https://www.epfl.ch/labs/imac/fr/recherche/smith_ian_fr/ Paolo De Los RiosPaolo De Los Rios earned his master in Electronic Engineering at the Turin Institute of Technology (Politecnico di Torino) in May 1993. In November 1993 he moved to Trieste, Italy, to enter the PhD program in Theoretical Condensed Matter Theory at the International School for Advanced Studies (SISSA/ISAS) where he obtained the PhD degree in October 1996 for his work on the statistical physics of disordered systems. After a one year postdoc at the Max-Planck Institute for the Physics of Complex Systems in Dresden, Germany, in November 1997 he moved to the University of Fribourg, Switzerland, to join the group of Prof. Yi-Cheng Zhang. There he has worked on various applications of statistical physics to complex systems. In September 2000 he has been appointed Assistant Professor in Statistical Physics of Living Matter and Complex Systems at the Institute of Theoretical Physics of the University of Lausanne, Switzerland. Since April 2010 he is Associate Professor at the Institute of Theoretical Physics of the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
