Publications associées à Espace épidural

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

EPFL2019

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Marco Capogrosso, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

Arthur Edouard Hirsch

Neuroprosthetic devices are engineered to study, support or replace impaired functions of the nervous system. The neural interface is an essential element of neuroprosthetic systems as it allows for transduction of signals and stimuli of desired functions ...

EPFL2018

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Eduardo Martin Moraud, Tomislav Milekovic, Marco Capogrosso, Pavel Musienko, Nicolas Vachicouras

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Who said fat is bad? Skull-stripping benefits from additional fat image

Tobias Kober, Delphine Ribes Lemay, Reto Meuli, Gunnar Krüger

Being a preliminary step for many clinical applications and analyses, accurate skull-stripping is a key challenge in MR brain imaging. One of its major difficulties arises from the contrast similarities at brain/non-brain tissue interfaces, in particular b ...

2011

Reduction of brain metastases in plasminogen activator inhibitor-1 deficient mice with transgenic ocular tumors

Friedrich Beermann

Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency in a transgenic mouse model of ocular tumors originat ...

Oxford University Press2008