Concept
Fonction (biologie)
Publications associées (30)
Bioengineering human mini-intestines with in vivo-like complexity and function
Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...
EPFL2023Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams
Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Tyler Joe Kohler, Stylianos Fodelianakis, Paraskevi Pramateftaki, Vincent Henri De Staercke, Matteo Tolosano, Michail Styllas, Martina Andrea Schön
In glacier-fed streams, ecological windows of opportunity allow complex microbial biofilms to develop and transiently form the basis of the food web, thereby controlling key ecosystem processes. Using metagenome-assembled genomes, we unravel strategies tha ...
Springer2022Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Philipp Bucher, Maryse Fiche, Valentina Scabia, Patrik Aouad, Fabio De Martino
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...
2021Population pharmacokinetic model selection assisted by machine learning
Jan Sickmann Hesthaven, Nadia Terranova
A fit-for-purpose structural and statistical model is the first major requirement in population pharmacometric model development. In this manuscript we discuss how this complex and computationally intensive task could benefit from supervised machine learni ...
SPRINGER/PLENUM PUBLISHERS202190 YEARS OF PROGESTERONE Progesterone receptor signaling in the normal breast and its implications for cancer
Cathrin Brisken, Valentina Scabia
Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges on breast carcinogenesis. Both s ...
BIOSCIENTIFICA LTD2020Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen
Kei Sakamoto, Maria Deak, Caterina Collodet
PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK) 16), is a Ser/Thr kinase that has been implicated in many cellular processes, including cell cycle, spermatogenesis, neurite outgrowth, and vesicle trafficking. Most recently, it has been propo ...
2019Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii
Bruno Lemaitre, Florent François Masson, Juan Camilo Paredes Escobar, Mario Gonzalo Garcia Arraez
BackgroundInsects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic nature of such associations is put in ...
2019Causal role of the inferolateral prefrontal cortex in balancing goal-directed and habitual control of behavior
Successful adaptation to complex environments depends on the balance of at least two systems: a flexible but slow goal-directed system encoding action-outcome associations and an efficient but rigid habitual system linking responses to preceding stimuli. R ...
Nature Publishing Group2018