Concept
Squalène
Publications associées (4)
Squalene Depletion in Skin Following Human Exposure to Ozone under Controlled Chamber Conditions
A major component of human skin oil is squalene, a highly unsaturated hydrocarbon that protects the skin from atmospheric oxidants. Skin oil, and thus squalene, is continuously replenished on the skin surface. Squalene is also quickly consumed through reac ...
Amer Chemical Soc2024Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor
Maria Josefina Marcaida Lopez, Michele Cascella, Christos Lamprakis
We present the crystal structures of the SEC14-like domain of supernatant protein factor (SPF) in complex with squalene and 2,3-oxidosqualene. The structures were resolved at 1.75 angstrom (complex with squalene) and 1.6 angstrom resolution (complex with 2 ...
Academic Press Inc Elsevier Science2015A molecular view of cholesterol-induced condensation in a lipid monolayer
We investigate the interrnolecular interactions in a mixed phospholipid/cholesterol monolayer using the surface-specific technique of vibrational sum frequency generation. This technique allows us to monitor the conformational and orientational order in th ...
2004Recent progress in the synthesis of zaragozic acids and analogs
Zaragozic acids (or squalestatins) are very potent inhibitors of squalene synthase. They or simpler analogs have potential as drugs for lowering the endogenous level of cholesterol in human serum. These compounds are Ras farnesyltransferase inhibitors and ...
2001