Concept
Syndrome de Li-Fraumeni
Publications associées (10)
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial
PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low-grade glioma (pLGG) on the basis of phosphatidylinositol 3-kinase (PI3K)/AKT/mammali ...
2023Discovery and Development of Hyperthermia-Enhanced Treatments for Malignant Skin and Uveal Melanomas
Melanomas are among the deadliest cancers, with a high predisposition to metastasis and a bad prognosis in their late stages. The effectiveness of current therapeutic regimens remains suboptimal, and despite initial successes, treatment resistance emerges ...
EPFL2023A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer
Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chromatin topology an ...
EPFL2019Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors
Douglas Hanahan, Mohammad Sadegh Saghafinia, Giovanni Ciriello, Marco Mina
The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify a ...
CELL PRESS2018Exome Sequencing Reveals Primary Immunodeficiencies in Children with Community-Acquired Pseudomonas aeruginosa Sepsis
Jacques Fellay, Istvan Bartha, Samira Asgari, Christoph Berger, Richard Wong
One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseu ...
Frontiers Media Sa2016