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Publications associées (32)
Rational Design of Chemically Controlled Antibodies and Protein Therapeutics
Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Pablo Gainza Cirauqui, Anthony Marchand, Leo Scheller, Lucia Bonati, Stéphane Rosset, Sailan Shui
Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...
2023Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability
Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...
EPFL2023Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit
Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...
EPFL2023Expanding computational biochemistry towards complex and non-natural compounds
In the beginning was the metabolism. The biochemical processes that make life possible transformed the soup of chemicals into the life on Earth we know today. Since then, living organisms have evolved, and life on Earth has become more complex. Living orga ...
EPFL2023Highly Sensitive Detection of the Antidepressant Fluoxetine With an Extended Gate Field Effect Transistor
Mihai Adrian Ionescu, Shokoofeh Sheibani
Fluoxetine (FL) is one of the selective serotonin reuptake inhibitors, which is used as an anti-depressant, as well as anti-panic drug. In this work, a sensor for label-free recognition of trace amounts of FL is introduced, which is based on an extended ga ...
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration
Multiple studies have found that increasing histone acetylation by means of histone deacetylase inhibitor (HDACi) treatment can ameliorate memory and rescue cognitive impairments, but their mode of action is not fully understood. In particular, it is uncle ...
2020Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications
Sandro Carrara, Danilo Demarchi, Simone Aiassa
The recent advancements in electrochemical measurements are guiding the development of new platforms for in situ point-of-care monitoring of human-metabolite, markers, and drugs. Despite this, the application of voltammetry-based sensing (VBS) techniques i ...
2019Histidine Targeting Heterobimetallic Ruthenium(II)-Gold(I) Complexes
Paul Joseph Dyson, Lucinda Kate Batchelor
Inspired by the preferential, allosteric binding of RAPTA-T and auranofin to the nucleosome core particle, we describe the design and synthesis of a series of heterobimetallic ruthenium(II)-gold(I) complexes with varying spacer lengths ranging from four to ...
2019Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Georg Fantner, John McKinney, Haig Alexander Eskandarian
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual cr ...
ELIFE SCIENCES PUBLICATIONS LTD2018Bioluminescent Antibodies for Point-of-Care Diagnostics
Kai Johnsson, Rudolf Griss, Alberto Schena, Qiuliyang Yu, Lin Xue
We introduce a general method to transform antibodies into ratiometric, bioluminescent sensor proteins for the no-wash quantification of analytes. Our approach is based on the genetic fusion of antibody fragments to NanoLuc luciferase and SNAP-tag, the lat ...
2017