Concept

Nouveau produit de synthèse

Publications associées (32)

Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42) relativ ...

2012

Detection of Farnesyltransferase Interface Hot Spots through Computational Alanine Scanning Mutagenesis

Marta Andreia Da Silva Perez

In this study, we present a detailed characterization of the full α/β interface in the farnesyltransferase (FTase) enzyme, an important target in drug design efforts. This characterization is presented in terms of hot spots, warm spots, and null spots and ...

2011

Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, part I: Priority list for environmental risk assessment of pharmaceuticals

Tamar Kohn, Chiara Perazzolo

Abstract—Pharmaceuticals are substances designed to have a biological effect in humans. Their presence in the environment, especially in surface waters, is of increasing concern because of their potential risk to non-target species. A large number of pharm ...

Society of Environmental Toxicology and Chemistry Press2010

Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Abhishek Garg

Personalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of ...

2009

C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones

Pierre Magistretti, Jean-René Cardinaux

Dopamine-induced changes in striatal gene expression are thought to play an important role in drug addiction and compulsive behaviour. In this study we report that dopamine induces the expression of the transcription factor CCAAT/Enhancer Binding Protein b ...

2006

Immobilized pH Gradient Gel Cell To Study the pH Dependence of Drug Lipophilicity

Hubert Girault, Christophe Roussel, Carlos Manuel De Melo Pereira, Hoang-Trang Lam

An experimental setup to study the pH dependence of standard ion-transfer potentials at the water/NPOE interface is presented. The system is composed of a micro-hole generated by laser photoablation in a 12-μm polyethylene terephthalate film, the aqueous p ...

2006

Wastewaters

The major pathways of human pharmaceuticals into the environment are from their use by individuals either at home or under medical supervision in hospitals, and to a lesser extent by the disposal of unwanted or out of date drugs. The administered pharmaceu ...

EPFL2005

Protein kinases as targets for anti-parasitic chemotherapy

Parasitic protozoa infecting humans have a staggering impact on public health, especially in the developing world. Furthermore, several protozoan species are major pathogens of domestic animals and have a considerable impact on food production. In many ins ...

2004

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Didier Trono, Laurence Gouzi Abrami, Priscilla Turelli

The membrane of human immunodeficiency virus type 1 (HIV-1) virions contains high levels of cholesterol and sphingomyelin, an enrichment that is explained by the preferential budding of the virus through raft microdomains of the plasma membrane. Upon deple ...

2002

Recent developments in reversing glycopeptide-resistant pathogens

Jieping Zhu

Review with 199 refs. Recent studies addressing vancomycin-resistance phenomena are surveyed. Besides leading semi-synthetic glycopeptides: BI-397 and LY 333328, other new synthetic derivs. are also presented. Rational design based on the known mode of act ...

1999

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