Concept
Primary tumor
Publications associées (89)
Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors
Cysteine cathepsins proteases are enzymes that play essential physiological roles, but their activity is also associated to different aspects of cancer progression and to the development of other diseases. Therefore, cysteine cathepsins are relevant and pr ...
EPFL2024Tumor dormancy: EMT beyond invasion and metastasis
Cathrin Brisken, Hazel Margaret Quinn, Patrik Aouad
More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from ...
WILEY2023Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis
Michele De Palma, Nahal Mansouri
Aims: Understanding the correlations between underlying medical and personal characteristics of a patient with cancer and the risk of lung metastasis may improve clinical management and outcomes. We used machine learning methodologies to predict the risk o ...
2023Investigating the effect of inflammation on the progression of B-cell lymphoma dissemination in the sentinel lymph node
Lymphomas are a group of heterogeneous blood cancers that arise from lymphocytes. The two primary clinical classifications of lymphomas are Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). In particular, B-cell lymphoma refers to the malignancies ...
EPFL2023Development of stimuli-responsive chemistry for tumor-targeted immunotherapy
Cancer immunotherapy is the science of boosting the immune response of patients to fight cancer. Recent advances have brought up treatments with huge success in the clinic. Patients with ad-vanced-stage cancers were long-term cured through checkpoint inhib ...
EPFL2023Metabolic dependencies of metastasis-initiating cells in breast cancer
Metastasis is the process by which cancer cells from the primary tumor travel through the blood stream to generate a secondary tumor site in a distant organ. Although very few cells are able to make this journey, the resulting effects are dire since most c ...
EPFL2023