Concept

Cellule souche embryonnaire

Publications associées (950)

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and gamma-secretase

Patrick Fraering, Sébastien Mosser, Eugenio Barone

Rapid remodeling of the actin cytoskeleton in the pre- and/or post-synaptic compartments is responsible for the regulation of neuronal plasticity, which is an important process for learning and memory. Cofilin1 plays an essential role in these processes an ...

Elsevier Science Bv2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Bernard Schneider, Liliane Glauser, Elpida Tsika, Darren Moore, Guillaume Daniel, Aris Nikolaos Fiser

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the ...

Oxford University Press2014

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos

Pierre Gönczy

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps during earlydevelopment. In this review, we discuss processes that set up the embryonic axes, with an emphasis onpolarity establishment and asymmetric division. W ...

WormBook2014

The chicken chorioallantoic membrane model in biology, medicine and bioengineering

Patrycja Nowak-Sliwinska

The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CA ...

Springer2014

Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers

Lucia Baldi Unser, Jutta Christine Wandrey, Sagar Shashidhar Manoli, Nino Zavradashvili, Tamar Memanishvili

The success of gene therapy depends on safe and effective gene carriers. Despite being widely used, synthetic vectors based on poly(ethylenimine) (PEI), poly(l-lysine) (PLL), or poly(l-arginine) (poly-Arg) are not yet fully satisfactory. Thus, both improve ...

Amer Chemical Soc2014

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Jeffrey Alan Hubbell, Mikaël Martino

In this work we have evaluated the capacity of bone morphogenetic protein-2 (BMP-2) and fibrin-binding platelet-derived growth factor-BB (PDGF-BB) to support cell growth and induce bone regeneration using two different imaging technologies to improve the u ...

Elsevier Sci Ltd2014

Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents

Paul Joseph Dyson, Tina Riedel

New polynuclear organometallic Platinum Group Metal (PGM) complexes containing di- and tripyridyl ester ligands have been synthesised and characterised using analytical and spectroscopic techniques including H-1, C-13 NMR and infrared spectroscopy. Reactio ...

2014

Strategy to Optimize the Biological Activity of Arene Ruthenium Metalla-Assemblies

Paul Joseph Dyson, Tina Riedel

Three new dinuclear arene ruthenium metalla-clips of the general formula [(p-cymene)(2)Ru2Cl2(mu-L)] have been prepared from {(p-cymene)(2)Ru2Cl2(p-Cl)(2)] and H2L organic linkers (H2La = diethyl-1,2-diazeneclicarboxylate, H2Lb = N,N'-bis(2-hydroxyethyl)ox ...

Amer Chemical Soc2014

A doppler effect in embryonic pattern formation

Andrew Charles Oates, Daniele Soroldoni

During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodical ...

2014

Characterizing the localization and role of lin-5 and era-1 mRNAs in early C. elegans embryos

Zoltán Péter Spiró

Asymmetric cell division is essential for the generation of diversity during development and the function of stem cell lineages. The Caenorhabditis elegans zygote is an attractive model to investigate the mechanisms of spindle positioning during asymmetric ...

EPFL2014

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