Concept

Transient receptor potential channel

Publications associées (37)

Aptamer-modified biosensors to visualize neurotransmitter flux

Chemical biosensors with the capacity to continuously monitor various neurotransmitter dynamics can be powerful tools to understand complex signaling pathways in the brain. However, in vivo detection of neurochemicals is challenging for many reasons such a ...

2022

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Yimon Aye, Yi Zhao

Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...

ROYAL SOC CHEMISTRY2020

Fluorescent Nanodiamonds as Versatile Intracellular Temperature Sensors

Aleksandra Radenovic, Vytautas Navikas, Evgenii Glushkov

Temperature is a widely known phenomenon, which plays an extremely important role in biological systems. Its behavior on the macro-scale has been quite well investigated and understood, thanks to the availability of reliable and precise thermometers such a ...

2019

A systematic investigation on the bactericidal transient species generated by photo-sensitization of natural organic matter (NOM) during solar and photo Fenton disinfection of surface waters

César Pulgarin, Stefanos Giannakis, Mona Kohantorabi, Ling Feng

In this work, the role of dissolved oxygen in the solar and the photo-Fenton-mediated E. coli inactivation process was put under scrutiny. The effect of transient species that were produced in the presence of various natural organic matter isolates (NOM), ...

ELSEVIER SCIENCE BV2019

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

Henning Paul-Julius Stahlberg

Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction. The free energy difference of cyclic-nucleotide (cAMP/cGMP) binding/unbinding is translated into mechanical work to modulate the open/closed probabilit ...

Springer Science and Business Media LLC2018

Effect of N-Terminal Myristoylation on the Active Conformation of Gα

Ursula Röthlisberger, Siri Camee van Keulen

G proteins are part of the G-protein-coupled receptor (GPCR) signal transduction cascade in which they transfer a signal from the membrane-embedded GPCR to other proteins in the cell. In the case of the inhibitory G-protein heterotrimer, permanent N-termin ...

2017

Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

Henning Paul-Julius Stahlberg

Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the confo ...

Springer Nature2016

Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa

Alexandre Louis André Persat, Joanne Netter Engel

Bacteria have evolved a wide range of sensing systems to appropriately respond to environmental signals. Here we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa detects contact with surfaces on short timescales using the mechanical activ ...

2015

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Henry Markram, Julie Meystre, Maurizio Ferdinando Pezzoli, Johannes Le Coutre, Susana Camacho Romero, Sara Lillian Gonzalez Andino

Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores how different AIS modulate neural response in layer 5 pyramidal neurons of S1 ne ...

Nature Publishing Group2014

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Grégoire Courtine, Isabel Laura Vollenweider

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...

Elsevier2014

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