Concept
Protéinopathie
Publications associées (162)
Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization.
Preventing the misfolding or aggregation of TDP-43 is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In our work, we provide proof of concept that native state stabili ...
EPFL2024Method of preparation of amyloidogenic protein aggregates and uses thereof
Hilal Lashuel, Galina Limorenko
The invention relates to methods for the preparation of method of preparation of Tau aggregates, including fibrils, fibrillar species, soluble and insoluble oligomeric species, new Tau aggregates and uses thereof. The invention further relates to the uses ...
2024Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs
Giovanni Dietler, Henning Paul-Julius Stahlberg, Meltem Tatli, Francesco Simone Ruggeri, Jiangtao Zhou, Salvatore Assenza, Raffaele Mezzenga
Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs cha ...
Wiley2024Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro
Hilal Lashuel, Yllza Jasiqi, Lixin Yang
TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...
Washington2023Discontinuous Galerkin methods for Fisher-Kolmogorov equation with application to a-synuclein spreading in Parkinson's disease
Alfio Quarteroni, Francesca Bonizzoni
This spreading of prion proteins is at the basis of brain neurodegeneration. This paper deals with the numerical modelling of the misfolding process of a-synuclein in Parkinson's disease. We introduce and analyse a discontinuous Galerkin method for the sem ...
Lausanne2023Fast Self-Assembly Dynamics of a beta-Sheet Peptide Soft Material
Sandor Kasas, Charlotte Martin
Peptide-based hydrogels are promising biocompatible materials for wound healing, drug delivery, and tissue engineering applications. The physical properties of these nanostructured materials depend strongly on the morphology of the gel network. However, th ...
WILEY-V C H VERLAG GMBH2023Classification of patients with cardiac amyloidosis using machine learning models on Italian electronic clinical health records
Silvestro Micera, Sara Mazzucato
Amyloidosis refers to a range of medical conditions in which misshapen proteins accumulate in various organs and tissues, forming insoluble fibrils. Cardiac amyloidosis is frequently linked to the buildup of misfolded transthyretin (TTR) or immunoglobulin ...
New York2023Deconstructing and Reconstructing the Complexity of Tau pathology
This thesis consists of four Chapters unified by a singular theme â how do we develop disease models that faithfully reproduce the pathology seen in patients suffering from neurodegenerative disorders associated with the Tau protein, such as Alzheimerâ ...
EPFL2023Trans‐seeding of Alzheimer‐related tau protein by a yeast prion
Henning Paul-Julius Stahlberg, Zhiva Skachokova
Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...
2022