Concept
Nicotinamide adénine dinucléotide phosphate
Publications associées (43)
Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations
Alterations in cellular nicotinamide adenine dinucleotide (NAD(+)) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD(+) precursors, or vitamin B3s, could ...
SPRINGER BASEL AG2022Adsorption Behavior of the Coenzyme NADH at the Carbon/ Electrolyte Interface Determined by Neutron Reflectometry
The adsorption behavior of beta-nicotinamide adenine dinucleotide (NADH) at the carbon/electrolyte interface has been studied using a combination of neutron reflectometry (NR) and solution depletion isotherms. Coupling the NR technique with an electrochemi ...
2022Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease
Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram
Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...
2021SLC25A51 is a mammalian mitochondrial NAD(+) transporter
Mitochondria require nicotinamide adenine dinucleotide (NAD(+)) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD(+) transporters have been identified in yeast and plants(1,2), but thei ...
NATURE RESEARCH2020NAD(+) homeostasis in health and disease
Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer
The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...
NATURE PUBLISHING GROUP2020Amoebocytes facilitate efficient carbon and nitrogen assimilation in the Cassiopea -Symbiodiniaceae symbiosis
Anders Meibom, Stéphane Laurent Escrig, Nils Rädecker, Louise Helene Soegaard Jensen, Niclas Heidelberg Lyndby, Sandrine Denise Françoise Bessette, Michael Kühl
The upside-down jellyfish Cassiopea engages in symbiosis with photosynthetic microalgae that facilitate uptake and recycling of inorganic nutrients. By con- trast to most other symbiotic cnidarians, algal endosymbionts in Cassiopea are not restricted to th ...
2020Regulation of cGAS- and RLR-mediated immunity to nucleic acids
Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...
NATURE PUBLISHING GROUP2020A biosensor for measuring NAD(+) levels at the point of care
Johan Auwerx, Kai Johnsson, Luc Patiny, Elena Katsyuba, Qiuliyang Yu, Lin Xue
The cellular level of nicotinamide adenine dinucleotide (NAD(+)), through its different functions, affects cellular metabolism and signalling(1-3). A decrease in the NAD(+) content has been associated with various pathologies and physiological aging(4,5), ...
NATURE PUBLISHING GROUP2019A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor
Carlos Canto Alvarez, Richardus Houtkooper, Sofia Moco
Objective: A decay in intracellular NAD(+) levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD(+) precursors can prevent, alleviate, or even reverse multiple metabolic complicati ...
ELSEVIER2019Niacin: an old lipid drug in a new NAD(+) dress
Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer
Niacin, the first antidyslipidemic drug, has been at the center stage of lipid research for many decades before the discovery of statins. However, to date, despite its remarkable effects on lipid profiles, the clinical outcomes of niacin treatment on cardi ...
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2019