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Publications associées (80)

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

The exact function of the adult brain neurogenesis remains elusive, although it has been suggested to play a role in learning and memory processes. In our studies, we employed cyclin D2 gene knockout (cD2 KO) mice showing impaired neurogenesis as well as d ...

2012

Learning Context Cues for Synapse Segmentation in EM Volumes

Pascal Fua, Graham Knott, Carlos Joaquin Becker, Karim Ali

We present a new approach for the automated segmentation of excitatory synapses in image stacks acquired by electron microscopy. We rely on a large set of image features specifically designed to take spatial context into account and train a classifier that ...

2012

A physiologically inspired model for global remapping in the hippocampus.

Alexander Mathis

Europe PMC is an archive of life sciences journal literature., A physiologically inspired model for global remapping in the hippocampus. ...

2011

Simultaneously driven linear and nonlinear spatial encoding fields in MRI

Daniel Gallichan, John Hennig

Spatial encoding in MRI is conventionally achieved by the application of switchable linear encoding fields. The general concept of the recently introduced PatLoc (Parallel Imaging Technique using Localized Gradients) encoding is to use nonlinear fields to ...

Wiley-Blackwell2011

Astrocyte-neuron lactate transport is required for long-term memory formation

We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essenti ...

2011

Learning under stress: the inverted-U-shape function revisited

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Basira Salehi

Although the relationship between stress intensity and memory function is generally believed to follow an inverted-U-shaped curve, strikingly this phenomenon has not been demonstrated under the same experimental conditions. We investigated this phenomenon ...

Cold Spring Harbor Laboratory Press2010

Is there a geometric module for spatial orientation? Insights from a rodent navigation model

Wulfram Gerstner, Ricardo Andres Chavarriaga Lozano, Thomas Strösslin, Angelo Arleo

Modern psychological theories of spatial cognition postulate the existence of a geometric module for reorientation. This concept is derived from experimental data showing that in rectangular arenas with distinct landmarks in the corners, disoriented rats o ...

American Psychological Association2009

Expression of brain-derived neurotrophic factor is not modulated by chronic mild stress in the rat hippocampus and amygdala

Pierre Magistretti, Jean-Luc Martin, Igor Allaman

Accumulating evidence supports a role for brain-derived neurotrophic factor (BDNF) in depression. However, most of these studies have been performed in animal models that have a low face validity with regard to the human disease. Here, we examined the regu ...

2009

Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area

Maria del Carmen Sandi Perez, Lisa Conboy

AMPA receptor-mediated synaptic modifications in the amygdala have been reported to sustain cued fear conditioning. However, the hippocampal formation is also critically involved in fear learning. Therefore, we examined whether fear conditioning is also ac ...

Wiley-Blackwell2009

AMPA receptor imaging by infrared scanning near-field optical microscopy

Giorgio Margaritondo, Kai Johnsson, Harald Hirling, Johanna Generosi, Michel Kropf

Infrared scanning near-field optical microscopy is used to detect AMPA-type glutamate receptor clusters in hippocampal neuron cells. AMPA's GluR2-subunits were marked with the fluorophore Alexa488 and high-resolution micrographs were taken at 6.25 µm wavel ...

2008

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