Concept

Neurotrophine

Publications associées (101)

Function Identification in Neuron Populations via Information Bottleneck

Michael Christoph Gastpar, Sreenivas Kartik Buddha

It is plausible to hypothesize that the spiking responses of certain neurons represent functions of the spiking signals of other neurons. A natural ensuing question concerns how to use experimental data to infer what kind of a function is being computed. M ...

MDPI AG2013

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping

Elisabeth Anne Dirren

Axonopathies are a group of clinically diverse disorders characterized by the progressive degeneration of the axons of specific neurons. In hereditary spastic paraplegia (HSP), the axons of cortical motor neurons degenerate and cause a spastic movement dis ...

American Society for Clinical Investigation2013

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Bernard Schneider, Christopher Towne, Isabelle Chang

Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels (Na(v)s) expressed in dorsal root ganglion (DRG) sensory neurons. The mechanisms underlying the alte ...

American Society for Clinical Investigation2013

Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/chondroitin sulfate proteoglycan 5

Pascal Escher

Purpose: To analyze in vivo the function of chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C (gene symbol: Cspg5) during retinal degeneration in the Rpe65(-/-) mouse model of Leber congenital amaurosis. ...

Molecular Vision2013

Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

Bernard Schneider, Stefano Carta

In the mammalian neocortex, segregated processing streams are thought to be important for forming sensory representations of the environment(1,2), but how local information in primary sensory cortex is transmitted to other distant cortical areas during beh ...

Nature Publishing Group2013

Nanotopography induced contact guidance of the F11 cell line during neuronal differentiation: a neuronal model cell line for tissue scaffold development

Silvestro Micera

The F11 hybridoma, a dorsal root ganglion-derived cell line, was used to investigate the response of nociceptive sensory neurons to nanotopographical guidance cues. This established this cell line as a model of peripheral sensory neuron growth for tissue s ...

2012

No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning

Friedhelm Christoph Hummel

Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BD ...

Public Library of Science2012

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Yiming Li, Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin, Lin Jin

Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites s ...

2012

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at the TRKA and p75NTR Promoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

Antonio Porro

Neuroblastoma is the most common extracranial solid tumor of childhood. One important factor that predicts a favorable prognosis is the robust expression of the TRKA and p75NTR neurotrophin receptor genes. Interestingly, TRKA and p75NTR expression is often ...

2011

Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures

Philippe Renaud, Dominique Zosso, Ana Valero, Anja Kunze

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we presen ...

Public Library of Science2011

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