Publications associées à Ultracentrifugeuse

Single-Chain Nanoparticles for Intracellular Drug Delivery

Single-chain nanoparticles (SCNPs) are a type of polymeric nanoparticles formed by collapsing/folding individual polymer chains via intra-molecular interactions. Their emergence holds promise to construct sub-20 nm polymeric nanoparticles with defined stru ...

EPFL2022

Control and Characterization of the Compactness of Single-Chain Nanoparticles

Francesco Stellacci, Luciano Andres Abriata, Lixia Wei, Suiyang Liao

Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs) have more undef ...

American Chemical Society2021

An Instrumented High-Speed Rotor with Embedded Telemetry for The Continuous Spatial Pressure Profile Measurement in Gas Lubricated Bearings: A Proof of Concept

Jürg Alexander Schiffmann, Karim Magdi Zakaria Abdelrahman Shalash

Pressure is one of the constitutional quantities governing the flow field in gas lubricated bearings. Knowledge of the pressure is of principal importance in the fundamental understanding of such bearings and for the calibration of reduced order models. Th ...

2020

An Instrumented High-Speed Rotor With Embedded Telemetry For The Continuous Spatial Pressure Profile Measurement In Gas Lubricated Bearings: A Proof Of Concept

Jürg Alexander Schiffmann, Karim Magdi Zakaria Abdelrahman Shalash

Gas lubricated bearings are capable of supporting high speed rotors with satisfactory load capacities. Pressure is one of the constitutional quantities governing the flow field in gas lubricated bearings. Knowledge of the pressure is of principal importanc ...

Amer Soc Mechanical Engineers2019

On the effect of ligand shell heterogeneity on nanoparticle/protein binding thermodynamics

Francesco Stellacci, Ahmet Bekdemir, Suiyang Liao

Nonspecific protein adhesion to nanoparticle (NP) has been proven to have important implications in nanomedicine. However, there are only a few examples of careful studies relating protein binding thermodynamics to NP physicochemical features. In particula ...

2019

Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation

Francesco Stellacci, Randy Patrick Carney, Jiwon Kim

Nanoparticles are finding many research and industrial applications, yet their characterization remains a challenge. Their cores are often polydisperse and coated by a stabilizing shell that varies in size and composition. No single technique can character ...

Nature Research2011

Analytical ultracentrifugation to support the development of biomaterials and biomedical devices

Jeffrey Alan Hubbell, Jutta Christine Wandrey, Conlin O'Neil, Urara Hasegawa

Analytical ultracentrifugation (AUC) primarily serves to investigate hydrodynamic and thermodynamic properties of natural and synthetic macromolecules and colloids in solution, dispersion or suspension. Beside such more conventional use, AUC can support ma ...

2011

Aqueous solution self-assembly of polystyrene-b-poly(L-lysine) diblock oligomers

Harm-Anton Klok, Harald Nuhn

This paper reports on the dilute, aqueous solution self-assembly of two asymmetric polystyrene-b-poly(L-lysine) (PSnPKm) diblock oligomers with PS and PK number-average degrees of polymerization of eight, respectively, 40 and 60. The self-assembly of these ...

2011

Extracellular matrix binding mixed micelles for drug delivery applications

Jeffrey Alan Hubbell, Davide Demurtas, Jutta Christine Wandrey

Received 5 January 2009 Accepted 22 March 2009 Available online 27 March 2009 Keywords: Mixed micelles Drug delivery Block copolymers Sirolimus Extracellular matrix We present the formation of collagen-binding mixed micelles and their potential suitability ...

2009

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

Hilal Lashuel, Bruno Claude Daniel Fauvet, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk

Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. Current therapeutic strategies for targeting MIF focus on ...

American Chemical Society2009