Publications associées à Succinate déshydrogénase

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Hilal Lashuel, Yogesh Singh Chauhan, Florian Lang, Joan Romani Aumedes, Yogesh Singh

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

BMC2023

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Pierre Vogel, Florence Pojer, Somi Reddy Majjigapu, George Coukos, Olivier Michielin

The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism. Many IDO1 inhibitors with different chemo ...

AMER CHEMICAL SOC2021

Generation of hydroxyl radical during chlorination of hydroxyphenols and natural organic matter extracts

Urs von Gunten, Eva Maria Rodriguez Franco

The generation of hydroxyl radicals ((OH)-O-center dot) during the chlorination of air saturated solutions of different hydroxyphenols (hydroquinone, resorcinol, catechol, gallic and tannic acids) at pH 7 has been determined by the formation of phenol (in ...

2020

Pivotal role of the redox-active tyrosine in driving the water splitting catalyzed by photosystem II

Daniele Narzi, Leonardo Guidoni

Photosynthetic water oxidation is catalyzed by the Mn4Ca cluster in photosystem II (PSII). The nearby redox-active tyrosine (Y-Z) serves as a direct electron acceptor of the Mn4Ca cluster and it forms a low-barrier H-bond (LBHB) with a neighboring histidin ...

ROYAL SOC CHEMISTRY2020

Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Qian Wang, Jieping Zhu, Xu Bao

The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp3)–H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-establi ...

Springer2019

Mechanism(s) of electron transfer and metabolic changes during iron reduction by Clostridium acetobutylicum

Cornelia List

Microorganisms catalyze many of the redox transformations driving the iron cycle in the geosphere. For instance, iron cycling includes the reduction of solid-phase and soluble ferric iron (Fe(III)) to ferrous iron (Fe(II)). However, in order to reduce soli ...

EPFL2019

Experimental evidence for long-range stabilizing and destabilizing interactions between charge and radical sites in distonic ions

Ganna Gryn'ova

Polarizable radical sites in distonic radical anions are stabilized by ostensibly remote negative charges. Computational evidence suggests bond dissociation energies of closed-shell precursors are significantly lowered by through-space interactions with a ...

ELSEVIER SCIENCE BV2019

The small RNA RyhB is a regulator of cytochrome expression in Shewanella oneidensis

Rizlan Bernier-Latmani, Karin Lederballe Meibom

Shewanella oneidensis produces an extensive electron transfer network that results in metabolic flexibility. A large number of c-type cytochromes are expressed by S. oneidensis and these function as the fundamental electron transport chain proteins. Althou ...

Frontiers Media SA2018

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Johan Auwerx, Davide D'Amico

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify ...

Rockefeller University Press2017

Reliable Performance Characterization of Mediated Photocatalytic Water-Splitting Half Reactions

Sophia Haussener, Meng Lin, Lihao Han

Photocatalytic approaches using two sets of semiconductor particles and a pair of redox shuttle mediators are considered as a safe and economic solution for solar water splitting. Here, we report on accurate experimental characterization techniques for pho ...

Wiley-V C H Verlag Gmbh2017