Concept
Vincristine
Publications associées (4)
Dearomatization of electron poor six-membered N-heterocycles through [3+2] annulation with aminocyclopropanes
Jérôme Waser, Johannes Preindl, Shyamal Chakrabarty
Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines and isoquinolines reacted with donor- ...
2017Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring
To ensure efficacy but avoid toxicity, many drugs require monitoring of their concentrations in the patient’s blood during therapy. Currently, therapeutic drug monitoring (TDM) is done in diagnostic laboratories that need trained personnel and expensive in ...
EPFL2013Chiasmatic Infiltration Secondary to Late Malignant Transformation of Retinoma
Purpose: To report the lethal course of malignant transformation of retinoma in an adult. Methods: Case report. A 40-year-old patient presented with retinoma in his right eye and retinoblastoma in his left eye. Enucleation was recommended but refused and t ...
Informa Healthcare2012Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers
Nanopharmaceuticals or nanomedicines are defined as nanometer sized (1 to 1000 nm) complex systems, consisting of at least two components, one of which being the biologically active moiety such as a drug, peptide, protein or nucleotide. Several nano-sized ...
EPFL2010