Concept
Encéphalopathie hépatique
Publications associées (50)
Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset
Cristina Ramona Cudalbu, Dunja Simicic
1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats recei ...
Zenodo2023New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023Lessons on brain edema in HE: from cellular to animal models and clinical studies
Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...
SPRINGER/PLENUM PUBLISHERS2023Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data
Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy
Magnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1 ...
EPFL2022Recent Developments on the Use of Nanomaterials for the Treatment of Epilepsy
Sandrine Gerber, Sara María Garcia Pedrero
Epilepsy affects more than 40 million people worldwide, constituting one of the most debilitating disorders of the Central Nervous System (CNS). It results from an imbalance in the electrical activity of neurons, which is primarily mediated by calcium ions ...
2022Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Bart Deplancke, Wouter Saelens
The liver is the largest solid organ in the body, yet it remains incompletely characterized. Here we present a spatial proteogenomic atlas of the healthy and obese human and murine liver combining single-cell CITEseq, single-nuclei sequencing, spatial tran ...
CELL PRESS2022Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field
This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field.
In the first two chapters, we studied longitudinally t ...
EPFL2021C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy
Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patients with COVID-19 ...
SPRINGER WIEN2021Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology
Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun
Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...
2021