Concept

Subgranular zone

Publications associées (97)

Glycogen metabolism as a marker of astrocyte differentiation

Pierre Magistretti, Igor Allaman, Luc Pellerin

Glycogen is a hallmark of mature astrocytes, but its emergence during astrocytic differentiation is unclear. Differentiation of E14 mouse neurospheres into astrocytes was induced with fetal bovine serum (FBS), Leukemia Inhibitory Factor (LIF), or Ciliary N ...

2009

Recruiting new neurons from the subventricular zone to the rat postnatal cortex: an organotypic slice culture model

The neurogenic subventricular zone (SVZ) of the lateral ventricle is a potential source for neuronal replacement in the postnatal or adult neocortex after injury. Here we present a novel model system to directly explore the cellular mechanisms of this proc ...

2008

Using Animal Models to Investigate the Functions of Adult Hippocampal Neurogenesis

Arnaud Fragnière

To investigate the function(s) of adult hippocampal neurogenesis, behavioral testing with two different animal models was conducted. The first model utilised transgenic mice expressing a Wnt signalling inhibitor (dnWNT) in the DG to knock-down neurogenesis ...

2008

Prospective identification of hematopoietic and neural stem/progenitor cells using transgenic and lentiviral based approaches

Didier Surdez

Adult stem cells represent only a minor proportion of a given tissue and are difficult to amplify in vitro without affecting their biological properties. To circumvent this problem, we used a transgenic/lentiviral based approach to isolate and characterize ...

EPFL2008

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinsons disease

Romain Zufferey

Neural stem cells (NSCs) are widely endorsed as a cell source for replacement strategies in neurodegenerative disease. However, their usefulness is currently limited by the inability to induce specific neurotransmitter phenotypes in these cells. In order t ...

Oxford University Press2008

Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule

Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Thomas Brionne

In this study, we examined whether chronic stress in adulthood can exert long-term effects on spatial-cognitive abilities and on the survival of newborn hippocampal cells in aging animals. Male Wistar rats were subjected to chronic unpredictable stress at ...

Lippincott, Williams & Wilkins2008

Enhancing the Reliability and Throughput of Neurosphere Culture on Hydrogel Microwell Arrays

Matthias Lütolf, Stefan Kobel, Monika Limacher

The neurosphere assay is the standard retrospective assay to test the self-renewal capability and multipotency of neural stem cells (NSC) in vitro. However, it has recently become clear that not all neurospheres are derived from a NSC and that on conventio ...

2008

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex

Freddy Radtke

Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecul ...

2008

Cellular mechanisms regulating adult neurogenesis and olfactory perception in mice

Maria del Carmen Sandi Perez, Thomas Brionne

In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...

EPFL2007

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

Patrick Aebischer

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by rapid loss of muscle control and eventual paralysis due to the death of large motor neurons in the brain and spinal cord. Growth factors such ...

Public Library of Science2007

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