Concept

Nerve guidance conduit

Publications associées (76)

Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: Ligand co-presentation and 3D-localization

Polymer brushes prepared via surface-initiated polymerization of 2-hydroxyethyl methacrylate are powerful platforms for the fabrication of model biointerfaces to study cell-substrate interactions. In this manuscript, the versatility of surface-initiated po ...

Elsevier2015

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Stéphanie Lacour, Alba Carla De Luca

Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative ...

Shenyang Editorial Dept Neural Regeneration Res2014

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Michele Giugliano

The search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore damaged brain functions is at the forefront ...

Beilstein-Institut2014

In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits

Graham Knott, Bohumil Maco

To what extent, how and when axons respond to injury in the highly interconnected grey matter is poorly understood. Here we use two-photon imaging and focused ion beam-scanning electron microscopy to explore, at synaptic resolution, the regrowth capacity o ...

2013

Cell Guidance on Nanogratings: A Computational Model of the Interplay between PC12 Growth Cones and Nanostructures

Silvestro Micera

Background: Recently, the effects of nanogratings have been investigated on PC12 with respect to cell polarity, neuronal differentiation, migration, maturation of focal adhesions and alignment of neurites. Methodology/Principal Findings: A synergistic proc ...

Public Library Science2013

A computer-assisted multi-electrode patch-clamp system

Henry Markram, Rodrigo de Campos Perin

The patch-clamp technique is today the most well-established method for recording electrical activity from individual neurons or their subcellular compartments. Nevertheless, achieving stable recordings, even from individual cells, remains a time-consuming ...

Journal of Visualized Experiments2013

PDMS Microchannel Regenerative Peripheral Nerve Interface

Stéphanie Lacour, Katherine Marie Musick

We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 x 110 mu m(2)) channels through which axons extend and then reconnect to the muscles on the other side of the device. Throu ...

Ieee2013

Hdac6 deletion delays disease progression in the SOD1(G93A) mouse model of ALS

Johan Auwerx

Defects in axonal transport are thought to contribute to the pathogenesis of neurodegenerative disease. Because -tubulin acetylation facilitates axonal transport, inhibition of the -tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and silent in ...

Oxford University Press2013

Off-the-shelf human decellularized tissue-engineered heart valves in a non-human primate model

Peter Modregger, Marco Stampanoni, Chad Brokopp

Heart valve tissue engineering based on decellularized xenogenic or allogenic starter matrices has shown promising first clinical results. However, the availability of healthy homologous donor valves is limited and xenogenic materials are associated with i ...

Elsevier2013

Surface Microstructures on Planar Substrates and Textile Fibers Guide Neurite Outgrowth: A Scaffold Solution to Push Limits of Critical Nerve Defect Regeneration?

Thomas Lehnert, Li Yao

The treatment of critical size peripheral nerve defects represents one of the most serious problems in neurosurgery. If the gap size exceeds a certain limit, healing can't be achieved. Connection mismatching may further reduce the clinical success. The pre ...

Public Library Science2012

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