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This work aims to develop arrays of individually actuated cell force spectroscopy probes. Cross et al. (Nat. Nanotech. 2007) have shown that human cells undergo substantial mechanical changes as they become cancerous. Cell force spectroscopy using AFM has ...
Heterotrimeric G-proteins are integral to a conserved regulatory module that influences metazoan asymmetric cell division (ACD). In the Caenorhabditis elegans zygote, GOA-1 (Galpha(o)) and GPA-16 (Galpha(i)) are involved in generating forces that pull on a ...
In alpine ski racing the relationships between skier kinetics and kinematics and their effect on performance and injury-related aspects are not well understood. There is currently no validated system to determine all external forces simultaneously acting o ...
Background: Studying the responses in human behaviour to external perturbations during daily motor tasks is of key importance for understanding mechanisms of balance control and for investigating the functional response of targeted subjects. Experimental p ...
This research is focusing on the implementation, testing, and analysis of quadrupedal, bio-inspired robot locomotion. Our tool of research is a light-weight, quadruped robot of the size of a house cat, both in simulation and hardware. We are currently foll ...
Two surgical treatments exist for ankle osteoarthritis (AO): ankle arthrodesis (AA) and total ankle replacement (TAR). Due to advantages and drawbacks of each treatment, decision making about these treatments is still a clinical question and thus, their ou ...
Asymmetric cell division is critical for generating daughter cells that possess distinct fates during development and in stem cell lineages. Correct orientation of the mitotic spindle with respect to the polarity axis is crucial to this process. In the one ...
Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between polarity cues and spindle positioning, but how this coupling is achieved is poorly understood. In one-cell stage Caenorhabditis elegans embryos, polarity cues set ...
This study aimed to use the plantar pressure insole for estimating the three-dimensional ground reaction force (GRF) as well as the frictional torque (T-F) during walking. Eleven subjects, six healthy and five patients with ankle disease participated in th ...
For many years, calorimetry has been recognized as a powerful and universal tool for monitoring chem. and biol. processes. A lab.-scale reaction calorimeter (RC1, Mettler-Toledo), initially developed for chem. reaction studies with a sensitivity of 100-150 ...