Concept
Résidu (biochimie)
Publications associées (14)
Development of Photocatalysts towards the Visible-Light driven C-Terminal Bioconjugation of Peptides and Proteins
If small molecules have led to tremendous progress in curing diseases, new therapeutic agents such as peptides or antibody-drugs conjugates have emerged as a highly promising next generation of pharmaceuticals. As for small molecules, their derivatization ...
EPFL2020Crosslinking Allosteric Sites on the Nucleosome Core Particle
Designing compounds that bind to the acidic patch of the nucleosome core particle (NCP) is an emerging therapeutic approach that can inhibit the binding of key chromatin factors. Pretreatment of human ovarian carcinoma, A2780, cells with RAPTA-T, an antime ...
EPFL2019Robust Driving Forces for Transmembrane Helix Packing
The packing structures of transmembrane helices are traditionally attributed to patterns in residues along the contact surface. In this view, besides keeping the helices confined in the membrane, the bilayer has only a minor effect on the helices structure ...
2012