Concept
Amantadine
Publications associées (16)
Virucidal compounds and use thereof
Francesco Stellacci, Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Corey Alfred Stevens, Francesca Olgiati, Chiara Medaglia, Lukasz Richter
Disclosed herein are peptide-grafted compounds that irreversibly deactivate bacteriophages or influenza virus depending on the peptide and remain safe for bacteria and mammalian cells. The active compounds comprise a core (cyclodextrin or gold nanoparticle ...
2024Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin
Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu, Marine Batista, Andrey Sysoev
We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified beta-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model eve ...
MDPI2023Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia
Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...
ELSEVIER SCI LTD2022Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Gerardo Turcatti, Fabien Kuttler, Michael Bauer, Liliane Yang
Endemic human coronaviruses (hCoVs) 229E and OC43 cause respiratory disease with recurrent infections, while severe acute respiratory syndrome (SARS)-CoV-2 spreads across the world with impact on health and societies. Here, we report an image-based multicy ...
2022Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism
Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun
Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...
2018Dopaminergic modulation of cortical motor network lateralization
Michael Herzog, Bogdan Draganski, Maya Anna Jastrzebowska, Lester Melie Garcia, Renaud Marquis
Introduction Unilateral movements are primarily processed in contralateral cortical and subcortical areas and additionally in ipsilateral cerebellum, leading to an asymmetric pattern of neural activation. Decrease of lateralization is characteristic of agi ...
2018Synthesis of Adamantane Aminoethers with Antitubercular Potential
Background: Intrigued by the fact that aminoadamantane derivatives, bearing the active 1,2-ethylenediamine moiety, are promising antitubercular agents, we report herein the synthesis and the antitubercular evaluation of N,N'-substituded-4,4'-[adamantane-2, ...
Bentham Science Publ Ltd2017A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance
Jeffrey David Jensen, Claudia Bank, Li Jiang
The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...
Academic Press Ltd- Elsevier Science Ltd2016Evolution of the Influenza A Virus Genome during Development of Oseltamivir Resistance In Vitro
Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral particles from infected cells. However, the IAV ...
Amer Soc Microbiology2014Materials for neural interfaces
The treatment of disorders of the nervous system poses a major clinical challenge. Development of neuromodulation (i.e., interfacing electronics to nervous tissue to modulate its function) has provided patients with neuronal-related deficits a new tool to ...
2012