Publications associées à TLR4

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Andrea Ablasser, Baptiste Claude André Guey, Jonathan Jean-Pierre Ricci, Chong Liu, Pauline Ambre Melenec, Pengbiao Xu, Lingyun Li, Ying Liu

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA d ...

Nature Portfolio2024

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Jacques Fellay, Yu Zhang, Peng Zhang, Qian Zhang

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvac ...

BMC2023

Pleiotropic effects of mitochondria in aging

Johan Auwerx, Tanes Imamura de Lima, Adrienne Joëlle Laurence Mottis, Yang Li

Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental respon ...

SPRINGERNATURE2022

The Drosophila Baramicin polypeptide gene protects against fungal infection

Bruno Lemaitre, Mark Austin Hanson, Igor Iatsenko, Alice Marra

The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of effector peptides that are secreted into the haemolymph. Technical difficulties prevented the investigation of these short effector genes until the recent advent of ...

PUBLIC LIBRARY SCIENCE2021

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Samuel Rommelaere, Fanny Schüpfer, Florent François Masson, Alice Marra

Insects are frequently infected with heritable bacterial endosymbionts. Endosymbionts have a dramatic impact on their host physiology and evolution. Their tissue distribution is variable with some species being housed intracellularly, some extracellularly ...

2021

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Li Tang, Yugang Guo, Yuqing Xie, Min Gao, Armand Kurum, Kewen Lei, Yu Zhao, Xiaomeng Hu, Simon Bart M. Van Herck

Targeting the stimulator of interferon genes (STING) pathway with cyclic dinucleotides (CDNs), the natural STING agonists, is a promising immunotherapeutic strategy for cancer. However, the clinical application of natural CDNs as therapeutics is greatly hi ...

2021

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Johan Auwerx, Kristina Schoonjans, Qi Wang

The role and underlying mechanism of plasma membrane-bound G protein-coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that T ...

2020

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Beatrice Volpe, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery, Kathleen Shah

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

WILEY2020

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TLR4

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Tracking spatiotemporal localisation and interactions of the innate immune sensor STING

Pleiotropic effects of mitochondria in aging

The Drosophila Baramicin polypeptide gene protects against fungal infection

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

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Chattez avec Graph Search

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Pleiotropic effects of mitochondria in aging

The Drosophila Baramicin polypeptide gene protects against fungal infection

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury