Concept

DNA methylation

Publications associées (276)

KAP1 controls endogenous retroviruses in embryonic stem cells

Didier Trono, Daniel Constam, Jacques Rougemont, Sonia Verp, Séverine Reynard, Helen Mary Rowe, Johan Jakobsson, Pierre Maillard, Hillary Layard-Liesching

More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-ty ...

Nature Publishing Group2010

GermOnline 4.0 is a genomics gateway for germline development, meiosis and the mitotic cell cycle

Alexandre Gattiker

GermOnline 4.0 is a cross-species database portal focusing on high-throughput expression data relevant for germline development, the meiotic cell cycle and mitosis in healthy versus malignant cells. It is thus a source of information for life scientists as ...

2010

Developement of a gateway compatible system for speciﬁc DNA integration in mouse embryonic stem cells and evaluation of the effect of nucleosome positioning on gene expression

Julien Bryois

An emerging model views gene regulation as a competition for regulatory sequences between transcription factors and nucleosomes at thermodynamic equilibrium. A computational model of the DNA affinity of nucleosomes was recently developed allowing to predic ...

2010

Alternative promoter usage at the notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis

Freddy Radtke, Jialin Zhang

Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We identified promoters in Notch1 that drove the expression of Notch1 proteins in t ...

Elsevier2010

DNA-centered approaches to characterize regulatory protein–DNA interaction complexes

Bart Deplancke, Jovan Simicevic

Gene regulation is mediated by site-specific DNA-binding proteins or transcription factors (TFs), which form protein complexes at regulatory loci either to activate or repress the expression of a target gene. The study of the dynamic properties of these re ...

Royal Society of Chemistry2010

Optimizing Variable Ordering of BDDs with Double Hybridized Embryonic Genetic Algorithm.

This paper presents a new double hybridized genetic algorithm for optimizing the variable order in Reduced Ordered Binary Decision Diagrams. The first hybridization adopts embryonic chromosomes as prefixes of variable orders instead of complete variable or ...

2010

Role of Bicaudal-C in Left-Right Axis Formation and Kidney Morphogenesis

Charlotte Maisonneuve

The KH domain RNA binding protein Bicaudal-C is known to play a role in anterior-posterior (AP) patterning in Drosophila by acting on oskar mRNA. In mammals, its expression is induced at late gastrulation in the mesodermal layer of the ventral node. Renal ...

EPFL2010

A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the olig1 and olig2 locus

Didier Trono, Denis Duboule, Isabelle Barde, Sonia Verp, Marc Samuel Friedli, Jozsef Zakany

Finding sequences that control expression of genes is central to understanding genome function. Previous studies have used evolutionary conservation as an indicator of regulatory potential. Here, we present a method for the unbiased in vivo screen of putat ...

Public Library of Science2010

Epigenetic memory in induced pluripotent stem cells

Olaia Maria Naveiras Torres-Quiroga, Kyungjin Kim, Ji Hyun Kim

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods ...

2010

Capacitance DNA bio-chips improved by new probe immobilization strategies

Giovanni De Micheli, Sandro Carrara, Yusuf Leblebici, Luca Benini, Andrea Cavallini, Bruno Samori

Label-free DNA detection plays a crucial role in developing point-of-care biochips. Capacitance detection is apromising technology for label-free detection. However, data published in literature often show evident time drift, large standard deviation,scatt ...

2010

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