Concept
Endothelial progenitor cell
Publications associées (80)
Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization
Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer
Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...
FRONTIERS MEDIA SA2022The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner
Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the ...
CELL PRESS2021Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells
Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularis ...
ELIFE SCIENCES PUBLICATIONS LTD2020Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility
Paul Joseph Dyson, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tina Riedel
Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...
WILEY2019The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing
Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga
During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...
AMER SOC HEMATOLOGY2019Chemo-manipulation of tumor blood vessels by a metal-based anticancer complex enhances antitumor therapy
Paul Joseph Dyson, Hubert van den Bergh, Tina Riedel
Human pleural mesothelioma is an incurable and chemoresistant cancer. Using a nude mouse xenograft model of human pleural mesothelioma, we show that RAPTA-T, a compound undergoing preclinical evaluation, enhances tumor vascular function by decreasing blood ...
2018Reprogramming tumor blood vessels for enhancing immunotherapy
Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve ...
2017Design principles for therapeutic angiogenic materials
Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...
Nature Publishing Group2016TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer
George Coukos, Nicolas Jean Philippe Guex, Luc Henry, Ioannis Xenarios, Hans-Anton Lehr, Nathalie Rufer, Emanuela Marina Iancu
In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...
Taylor & Francis Inc2016