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Publications associées (11)
Organ-specific biotransformation in salmonids: Insight into intrinsic enzyme activity and biotransformation of three micropollutants
Kristin Schirmer, Juliane Hollender
Aquatic ecosystems continue to be threatened by chemical pollution. To what extent organisms are able to cope with chemical exposure depends on their ability to display mechanisms of defense across different organs. Among these mechanisms, biotransformatio ...
Elsevier2024De novo developed small cyclic peptides that are orally available
Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...
EPFL2022NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi, Anush Chiappino-Pepe
The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...
2021Algorithms and flowchart for the design of synthetic biochemical networks
New drugs are needed to assure effective therapies for previously untreated diseases, emerging diseases, and personalized medicine, but the process of drug development is complex, costly, and time-consuming. This is especially problematic considering that ...
EPFL2020Electrostatic spray ionization from 384-well microtiter plates for mass spectrometry analysis based enzyme assay and drug metabolism screening
Hubert Girault, Liang Qiao, Tzu-En Lin, Elena Tobolkina, Xiaoqin Zhong, Yan Deng, Emna Belghith
We have realized the direct ionization of samples from wells of microtiter plates under atmospheric conditions for mass spectrometry analysis without any liquid delivery system or any additional interface. The microtiter plate is a commercially available 3 ...
American Chemical Society2017Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia
Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good unders ...
Natl Acad Sciences2017New ionization and tagging methods for mass spectrometry
Mass spectrometry (MS) is an essential detection tool in bioanalytical chemistry owing to its exceptional selectivity and sensitivity, paired with rapid analyte identification and quantification. In this thesis, two classical MS and a newly developed ioniz ...
EPFL2017A neural approach to drugs monitoring for personalized medicine
Giovanni De Micheli, Sandro Carrara, Camilla Baj-Rossi, Marius Schirmer
The development of fast and mobile drug detection is an important aspect of personalized medicine. It enables the quick assessment of inter-individual differences in drug metabolism and corresponding adjustments of the dose. Recent developments of amperome ...
2015Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos
Background: In mammals, ABCB1 constitutes a cellular "first line of defense" against a wide array of chemicals and drugs conferring cellular multidrug or multixenobiotic resistance (MDR/MXR). We tested the hypothesis that an ABCB1 ortholog serves as protec ...
Biomed Central Ltd2013Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring
Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Abhishek Garg
Personalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of ...
2009