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The rate of formation of intramolecular interactions in unfolded proteins determines how fast conformational space can be explored during folding. Characterization of the dynamics of unfolded proteins is therefore essential for the understanding of the ear ...
Synthesis of Modified Prolines using aza naked sugar methodology R and S-prolines are secondary, cyclic, pyrrolidine-based amino acids. Proline demonstrated excellent catalytic activity to promote enantio- and diatereoselective, intra- and intermolecular c ...
Cyclodepsipeptides incorporating a sugar amino acid, e.g., I, have been synthesized. A three-component reaction of a sugar amino acid (SAA) deriv., an aldehyde, and a dipeptide isonitrile in refluxing methanol afforded the corresponding 5-aminooxazole whic ...
The invention relates to the prepn. of esters R1R2NCH2CH(Nu)CO2R3 (R1-R3 are protecting groups and Nu is a nucleophilic group) by reaction of R1R2NCH(CH2-Y)CO2R3 (Y is a leaving group) with a nucleophile. Thus, treatment of (R)-Bn2NCH(CH2O3SMe)CO2Me with N ...
A new method for the covalent and specific labeling of fusion proteins of carrier proteins (CPs) with small organic molecules has been developed in this work. This technology combines the convenience of expressing genetically tagged reporter proteins with ...
Iontophoretic delivery of a homologous series of cationic ALA esters, into and through the skin, has been detd. and compared to that of the zwitterionic parent drug. The roles of electrorepulsion and electroosmosis have been deduced. ...
A balanced supplementation method was applied to develop a serum and protein- free medium supporting hybridoma cell batch culture. The aim was to improve systematically the initial formulation of the medium to prevent limitations due to unbalanced concns. ...
The authors have prepd. beta-peptides I and II which contg. unlike-beta2,3-amino acids. The structures of beta-peptides I (prepd. in soln.) and II (prepd. on solid-phase) are reported. ...
Protoporphyrin IX (PpIX) is used as a fluorescence marker and photosensitizing agent in photodynamic therapy (PDT). A temporary increase of PpIX in tissues can be obtained by administration of 5-aminolevulinic acid (ALA). Lipophilicity is one of the key pa ...
Intrachain loop formation allows unfolded polypeptide chains to search for favorable interactions during protein folding. We applied triplet-triplet energy transfer between a xanthone moiety and naphthylalanine to directly measure loop formation in various ...
