Concept
Thérapie par l'écriture
Publications associées (4)
Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice
Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro
Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...
MARY ANN LIEBERT, INC2019Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine
Priscilla Suhasna Maithili Briquez
Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...
EPFL2016Development of Minimally-Invasive Optical Methods to Individualize the Doses Used for Therapeutic Applications of Light
Despite the experience gained over several decades in various types of light-based medical treatments, the optimization of the corresponding therapeutic protocols and accurate forecasting of their outcome have not yet been achieved in many cases. The diffi ...
EPFL2010High-dose chemotherapy augments the efficacy of recombinant adenovirus vaccines and improves the therapeutic outcome
We have investigated the therapeutic potential of a prototypic melanoma vaccine based on recombinant adenovirus expressing human dopachrome tautomerase in the B16F10 murine melanoma model. We found that in the presence of a tumor, the magnitude of T-cell i ...
2009