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This thesis introduces a new approach to characterize and evaluate ocular light exposure based on the discovery of novel blue light-sensitive photoreceptors in the human eye. These photoreceptors are the primary mediators of 'non-visual' responses impactin ...
The vertebrate retina is a model system of the development of the central nervous system. Because of its rapid development and the availability of many molecular tools the zebrafish is an established model of retinal development. Development and maintenanc ...
Background and Purpose: Transgenic mice over-expressing Notch2 in the uvea exhibit a hyperplastic ciliary body leading to increased IOP and glaucoma. The aim of this study was to investigate the possible presence of NOTCH2 variants in patients with primary ...
Eye movements consist of spherical rotations, with orientation generally constrained by Listing’s law. Our main result is a complete explicit formulation of ballistic eye movement under the Listing constraint. We present a conceptual framework for eye move ...
High dynamic range (HDR) imaging is able to capture a wide range of luminance values, closer to what the human eye can perceive. However, for capture and display technologies, it is important to answer the question on the significance of higher dynamic ran ...
In the last few years, we have witnessed impres-sive demonstrations of aggressive flights and acrobatics using quadrotors. However, those robots are actually blind. They do not see by themselves, but through the “eyes” of an external motion capture system. ...
The ciliary body and iris are pigmented epithelial structures in the anterior eye segment that function to maintain correct intra-ocular pressure and regulate exposure of the internal eye structures to light, respectively. The cellular and molecular factor ...
The importance of light not only as a therapeutic tool but as an essential element of healthy living has been highlighted by the recent discovery of a specialized photoreceptor in the eye responsible for synchronizing our internal circadian pacemaker. This ...
Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival and differentiation. In melanocytes, Notch signaling is essential for the maintenance of melanocytes and the melanocyte stem cell population. Whereas, ...
The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, ...
