Concept
Cellule souche pluripotente induite
Publications associées (603)
Theorizing the Emotional Quality of Teaching and Learning Relationships in STEM Faculty Development
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The emotional quality of learning relationships can affect student attainment and engagement and should, therefore, be a focus for STEM faculty development activities. This chapter introduces the range of ways in which educational relationships in STEM cla ...
Information Age Publishing2022In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture
In humans, mice, and other mammals key internal organs such as the gut, the lungs, the pancreas, and the liver all derive from the same embryonic tissue: the endoderm. The development of all of these structures thus depends on a same set of early cells, an ...
EPFL2022Annotation of spatially resolved single-cell data with STELLAR
Accurate cell-type annotation from spatially resolved single cells is crucial to understand functional spatial biology that is the basis of tissue organization. However, current computational methods for annotating spatially resolved single-cell data are t ...
2022PD-1-cis IL-2R agonism yields better effectors from stem-like CD8(+) T cells
Douglas Hanahan, Mélanie Louise Tichet, Petra Catalina Schwalie, Stephan Wullschleger, Maria Karagianni
Expansion and differentiation of antigen-experienced PD-1(+)TCF-1(+) stem-like CD8(+) T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade(1-4). Hashimoto et al. have shown that, in chronic infections, administr ...
NATURE PORTFOLIO2022Generation of a Gal4-dependent gene recombination and illuminating mouse
Cell labeling technologies, including the Cre/loxP system, are powerful tools in developmental biology. Although the conventional Cre/loxP system has been extensively used to label the expression of specific genes, it is less frequently used for labeling p ...
INT PRESS EDITING CENTRE INC2022Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth
Michele De Palma, Nadine Fournier, Stefanie Siegert, Mauro Delorenzi, Mario Leonardo Squadrito, Sina Nassiri, Pascale Anderle Pedone, Simone Ragusa, François Renevey
Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...
London2022TFIIH moonlighting at telomeres
Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in cells lacking telomerase due to the end replication problem. In addition, recent work uncovered that the ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2022Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
T memory stem cells (T-SCM) display increased self-renewal and prolonged survival capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell responses. T-SCM cells can be expanded by Urolithin A (UA), which is produced by the ...
CELL PRESS2022