Publications associées à Diploblastique

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation

TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 whe ...

Nature Publishing Group2016

Dual Lineage-Specific Expression of Sox17 During Mouse Embryogenesis

Anne Grapin-Botton, Marine Marie Kraus, Laurence Anne E Lemaire

Sox17 is essential for both endoderm development and fetal hematopoietic stem cell (HSC) maintenance. While endoderm-derived organs are well known to originate from Sox17-expressing cells, it is less certain whether fetal HSCs also originate from Sox17-exp ...

Wiley-Blackwell2012

The Role of Nodal Processing in Pluripotent Progenitors

Anja Dietze

Nodal and its co-receptors of the EGF-CFC family are essential during chordate development, both to maintain pluripotent progenitor cells and to subsequently coordinate their allocation to the different germ layers. How these distinct Nodal activities are ...

EPFL2011

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst

Daniel Constam

Axis formation and allocation of pluripotent progenitor cells to the germ layers are governed by the TGF-β-related Nodal precursor and its secreted proprotein convertases (PCs) Furin and Pace4. However, when and where Furin and Pace4 first become active ha ...

Rockefeller University Press2010

Running the gauntlet: an overview of the modalities of travel employed by the putative morphogen Nodal

Daniel Constam

A fundamental challenge in biology is to explain how progenitor cells in developing tissues acquire distinct fates according to their position. In vertebrates, the positional information that specifies the germ layers and the primary body axes is mediated ...

Elsevier2009

Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension

David Welchman

Drosophila germ-band extension (GBE) is an example of the convergence and extension movements that elongate and narrow embryonic tissues. To understand the collective cell behaviours underlying tissue morphogenesis, we have continuously quantified cell int ...

2009

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

Anne Grapin-Botton

BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of i ...

Public Library of Science2009

FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo

Anne Grapin-Botton

At the end of gastrulation in avians and mammals, the endoderm germ layer is an undetermined sheet of cells. Over the next 24-48 h, endoderm forms a primitive tube and becomes regionally specified along the anterior-posterior axis. Fgf4 is expressed in gas ...

2006

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Anne Grapin-Botton

This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stage ...

2005