Concept
Cancer du foie
Publications associées (179)
A microbial-derived succinylated bile acid to safeguard liver health
Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny
In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...
Cell Press2024Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1
Kristina Schoonjans, Petar Petrov
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...
Amsterdam2024Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme
Background Excessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capacity, i ...
Frontiers Media Sa2024Characterization of Cyclo His-Pro for the prevention and treatment of liver disease and muscular dystrophy
The natural compound Cyclo Histidine-Proline (CHP) was initially discovered in the brain, but thereafter evaluated in the context of diabetes because of its hypoglycemic action. The pharmacokinetics and the toxicological profile of CHP showed it can be dos ...
EPFL2023High field brain proton magnetic resonance spectroscopy and volumetry in children with chronic, compensated liver disease-A pilot study
Lijing Xin, Cristina Ramona Cudalbu, Bénédicte Marie Maréchal, Sarah Lachat
Background: There is increasing evidence that children or young adults having acquired liver disease in childhood display neurocognitive impairment which may become more apparent as they grow older. The molecular, cellular and morphological underpinnings o ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2023Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP
Henning Paul-Julius Stahlberg, Dongchun Ni
BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...
Berlin2023Lessons on brain edema in HE: from cellular to animal models and clinical studies
Cristina Ramona Cudalbu, Katarzyna Pierzchala, Jessie Julie Mosso
Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...
SPRINGER/PLENUM PUBLISHERS2023New insights into rodent brain microstructure and metabolism in hepatic encephalopathy
Type C hepatic encephalopathy (HE) is a severe neuropsychiatric complication of chronic liver disease, for which the prognosis is poor in the absence of liver transplantation. Cirrhosis in type C HE leads to a toxic accumulation of ammonia in the blood, wh ...
EPFL2023Social isolation shortens lifespan through oxidative stress in ants
Alessandro Crespi, Laurent Keller
Social isolation negatively affects health, induces detrimental behaviors, and shortens lifespan in social species. Little is known about the mechanisms underpinning these effects because model species are typically short-lived and non-social. Using coloni ...
Berlin2023Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression
The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...
EPFL2022