Publications associées à Cancer du foie

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Arnaud Comment, Hikari Ananda Infinity Yoshihara

As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...

2021

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun

Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...

2021

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

Kristina Schoonjans, Jian Liu, Bhoomika Mathur

Background & Aims: Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases. Methods: We performed high-throughput sequencing of ...

2020

Three dimensional models of tissue fibrosis

Kristina Schoonjans, Matthias Lütolf, Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020

Mechano-modulatory synthetic niches for liver organoid derivation

Kristina Schoonjans, Matthias Lütolf, Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz

The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling. The use of three-dimensional (3D) cultures based on ill-defined and potentially immunog ...

NATURE PUBLISHING GROUP2020

Causal inference with limited resources: proportionally-representative interventions

Mats Julius Stensrud, Aaron Leor Sarvet

Investigators often evaluate treatment effects by considering settings in which all individuals are assigned a treatment of interest, assuming that an unlimited number of treatment units are available. However, many real-life treatments are of limited supp ...

2020

Voxel2Mesh: 3D Mesh Model Generation from Volumetric Data

Pascal Fua, Graham Knott, Pamuditha Udaranga Wickramasinghe, Edoardo Remelli

CNN-based volumetric methods that label individual voxels now dominate the field of biomedical segmentation. However, 3D surface representations are often required for proper analysis. They can be obtained by post-processing the labeled volumes which typic ...

2020

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Vassily Hatzimanikatis, Vikash Kumar Pandey, Anush Chiappino-Pepe, Dominique Soldati-Favre

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We dis ...

CELL PRESS2019

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Cancer du foie

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Circadian dynamics of RNA localisation in the mammalian liver

Defined matrices for epithelial organoid culture and disease modelling

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

Three dimensional models of tissue fibrosis

Mechano-modulatory synthetic niches for liver organoid derivation

Causal inference with limited resources: proportionally-representative interventions

Voxel2Mesh: 3D Mesh Model Generation from Volumetric Data

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Graph Chatbot

Chattez avec Graph Search

Circadian dynamics of RNA localisation in the mammalian liver

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Defined matrices for epithelial organoid culture and disease modelling

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis

Mechano-modulatory synthetic niches for liver organoid derivation

Three dimensional models of tissue fibrosis

Voxel2Mesh: 3D Mesh Model Generation from Volumetric Data

Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage

Causal inference with limited resources: proportionally-representative interventions