Concept

Synthèse peptidique

Publications associées (466)

Highly-resolved Spectra of Gas-phase Gramicidin S: A Benchmark for Peptide Structure Calculations

We have measured a vibrationally-resolved UV spectrum of doubly-protonated gramicidin S (GS) in the gas phase and, subsequently, a highly-resolved, conformer-specific infrared spectra in the 6 μm fingerprint region, using a cold ion trap in combination wit ...

American Chemical Society2010

Acoustophoretic Synchronization of Mammalian Cells in Microchannels

Herbert Shea, Jonathan David Adams

We report the first use of ultrasonic standing waves to achieve cell cycle phase synchronization in mammalian cells in a high-throughput and reagent-free manner. The acoustophoretic cell synchronization (ACS) device utilizes volume-dependent acoustic radia ...

American Chemical Society2010

Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides

Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev

We report on the characteristics of the radical-ion-driven dissociation of a diverse array of beta-amino acids incorporated into alpha-peptides, as probed by tandem electron-capture and electron-transfer dissociation (ECD/ETD) mass spectrometry. The report ...

2010

Synthesis of Functional Polydepsipeptides via Direct Ring-Opening Polymerization and Post-Polymerization Modification

Harm-Anton Klok, Nadja Franz

This contribution explores different strategies for the synthesis of side chain functional polydepsipeptides. First, the ring-opening polymerization of side chain functional morpholine-2,5-diones is revisited and the optimized reaction conditions used for ...

2010

Efficient Synthesis of alpha -Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and alpha -Isocyanoacetamides

Jieping Zhu

Acyl chlorides R1COCl [R1 = Et, n-pentyl, PhCH2CH2, 2-cyclopentylethyl, (S)-PhCHEt] efficiently reacted with alpha -isocyanoacetamides R2R3NCOCH(NC)R4 (R2 = H, R3 = n-Bu, PhCH2, HC==CCH2; R2 = Me, R3 = HC==CCH2, PhCH2; R2R3N = 4-morpholinyl; R4 = H, Me, Ph ...

2010

Function and specificity of synthetic Hox transcription factors in vivo

Homeotic (Hox) genes encode transcription factors that confer segmental identity along the anteroposterior axis of the embryo. However the molecular mechanisms underlying Hox-mediated transcription and the differential requirements for specificity in the r ...

2010

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

Beat Fierz

We have developed a readily accessible disulfide-directed methodology for the site-specific modification of histones by ubiquitin and ubiquitin-like proteins. The disulfide-linked analog of mono-ubiquitylated H2B stimulated the H3K79 methyltransferase acti ...

2010

On Complete Functional Synthesis

Viktor Kuncak, Mikaël Mayer, Philippe Paul Henri Suter, Ruzica Piskac

Synthesis of program fragments from specifications can make programs easier to write and easier to reason about. To integrate synthesis into programming languages, synthesis algorithms should behave in a predictable way---they should succeed for a well-def ...

2009

Synthesis of Networks on Chips for 3D Systems on Chips

Giovanni De Micheli, Luca Benini, Srinivasan Murali, Ciprian Seiculescu

Three-dimensional stacking of silicon layers is emerging as a promising solution to handle the design complexity and heterogeneity of Systems on Chips (SoCs). Networks on Chips (NoCs) are necessary to efficiently handle the 3D interconnect complexity. Desi ...

2009

Recent Advances in the Liquid-Phase Synthesis of Metal Nanostructures with Controlled Shape and Size for Catalysis

Lioubov Kiwi

Recent advances in the liquid-phase synthesis of metal nanostructures of different sizes and shapes are reviewed regarding their catalytic properties. The controlled synthesis of nanostructures is based on the colloid chemistry techniques in the solution, ...

2009

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