Concept

Xénobiologie

Publications associées (24)

DNA origami nanostructures for controlled therapeutic drug delivery

Maartje Martina Cornelia Bastings, Jorieke Weiden

DNA nanostructures are emerging as a versatile platform for controlled drug delivery as a result of recent progress in production yield and strategies to obtain prolonged stability in biological environments. The construction of nanostructures from this un ...

2021

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Andrea Ablasser

Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detec ...

NATURE PUBLISHING GROUP2020

Synthetic Studies toward Amanita Phalloides Toxins

Philipp Georg Werner Seeberger

Amatoxins are ribosomally synthesized and post-translationally modified bicyclic octapeptides biosynthesized by the deadly basidiomycete fungus Amanita phalloides. Amongst this group, alpha-amanitin is the most widely known toxin and is currently under inv ...

EPFL2020

Quadruplet Selection Methods For Deep Embedding Learning

Erhan Gündogdu

Recognition of objects with subtle differences has been used in many practical applications, such as car model recognition and maritime vessel identification. For discrimination of the objects in fine-grained detail, we focus on deep embedding learning by ...

IEEE2019

Improving energy transfer efficiency of dye-sensitized solar cell by fine tuning of dye planarity

Ulf Anders Hagfeldt

Two push-pull metal-free sensitizers with 5,11-dihydroindolo[3,2-b]carbazole derivatives as electron-donating groups and 4-(benzo[c][1,2,5]thiadiazol-4-ylethynyl)benzoic acid (BTZ) as electron-withdrawing unit, denoted by SK201 and SK202, were synthesized ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Identification and characterisation of small-molecule inhibitors targeting STING

Simone Margret Haag

The recognition of pathogen-derived nucleic acids is a critical mechanism by which the innate immune system detects viral infection. Upon activation, nucleic acid sensors initiate the expression of type I interferons and other inflammatory mediators, subse ...

EPFL2019

Xeno Nucleic Acid Nanosensors for Enhanced Stability Against Ion-Induced Perturbations

Ardemis Anoush Boghossian, Carlo Gigli, Alice Judith Gillen, Justyna Kupis-Rozmyslowicz

The omnipresence of salts in biofluids creates a pervasive challenge in designing sensors suitable for in vivo applications. Fluctuations in ion concentrations have been shown to affect the sensitivity and selectivity of optical sensors based on single-wal ...

2018

More DNA–Aptamers for Small Drugs: A Capture–SELEX Coupled with Surface Plasmon Resonance and High-Throughput Sequencing

Carlotta Guiducci, Fabio Mario Spiga

To address limitations in the production of DNA aptamers against small molecules, we introduce a DNA-based capture-SELEX (systematic evolution of ligands by exponential enrichment) protocol with long and continuous randomized library for more flexibility, ...

ACS Publications2015

A computational framework for the design of optimal protein synthesis

Vassily Hatzimanikatis, Julien Racle, Jan Overney

Despite the establishment of design principles to optimize codon choice for heterologous expression vector design, the relationship between codon sequence and final protein yield remains poorly understood. In this work, we present a computational framework ...

Wiley-Blackwell2012

Structure and properties of Fe-modified Na_{0.5}Bi_{0.5}TiO_{3} at ambient and elevated temperature

Dragan Damjanovic

Sodium bismuth titanate (NBT) ceramics are among the most promising lead-free materials for piezoelectric applications. This work reports the crystal structure and phase evolution of NBT and Fe-modified NBT (from 0-2 at.% Fe) using synchrotron x-ray diffra ...

2012

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