Concept
Drug policy
Publications associées (54)
Personalized Drug Administrations Using Support Vector Machine
Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout
The decision-making process regarding drug dose, regularly used in everyday medical practice, is critical to patients’ health and recovery. It is a challenging process, especially for a drug with narrow therapeutic ranges, in which a medical doctor decides ...
2013Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause considerable morbidity and mortality worldwide. For the first time ...
Nature Publishing Group2013Drug development: longer-lived proteins
Stephane Kontos, Jeffrey Alan Hubbell
Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biop ...
2012Modeling a zero-order drug release pattern with multi-laminated hydrogels
Mohamadreza Nassajian Moghadam
Diffusion-controlled hydrogel polymeric matrix devices have been among the most widely used drug delivery systems. How ever in homogeneous hydrogel the diffusional distance increase with time and hence, the release rate decreases. That results in high rele ...
2012Automated design of ligands to polypharmacological profiles
The clinical efficacy and safety of a drug is determined by its activity profile across many proteins in the proteome. However, designing drugs with a specific multi-target profile is both complex and difficult. Therefore methods to design drugs rationally ...
Nature Publishing Group2012Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells
Paul Joseph Dyson, Michael Groessl
An approach to characterize the interactions of RAPTA-T, a novel ruthenium-based anticancer drug candidate with intriguing antimetastatic properties, with human ovarian cancer cells in vitro is described. The distribution profile of the metallodrug within ...
Royal Society of Chemistry2012Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates
Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate superior performance in vitro and in vivo. However, it i ...
American Chemical Society2012Streptomycin-Starved Mycobacterium tuberculosis 18b, a Drug Discovery Tool for Latent Tuberculosis
Stewart Cole, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Ming Zhang
Mycobacterium tuberculosis 18b, a streptomycin (STR)-dependent mutant that enters a viable but nonreplicating state in the absence of STR, has been developed as a simple model for drug testing against dormant bacilli. Here, we further evaluated the STR-sta ...
Amer Soc Microbiology2012Searching for the Protein Targets of Bioactive Molecules
Kai Johnsson, Christopher Chidley, Cindy Fellay, Hirohito Haruki, Miriam Grønlund Pedersen, Simone Moser
The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal phy ...
Schweizerische Chemische Gesellschaft2011