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The very existence of urban formations on all inhabited continents and throughout the history of mankind since the 3rd millennium B.C. leads to suppose a tendency of some structured societies to maximize interaction by minimizing physical distance. Were th ...
Multimedia fate and multipathway human,exposure models are widely adopted in assessments of toxicological risks of chemical emissions at the regional scale. This paper addresses the question of how much spatial detail is necessary in such models when estim ...
The sound development of city-regions presents a major planning challenge, as these regions are and will be the living spaces for the majority of the population. Therefore, a key question is how city- regions can be managed so that they develop in a sustai ...
Implementing sustainable development (SD) requires operationalizing this rather vague guiding principle in a socio-technological context. This paper refers to a notion of SD that stresses approaching SD from a systemic perspective. We first present the Fun ...
Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and PD pa ...
