Publications associées à Récepteur couplé aux protéines G

Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1

Ursula Röthlisberger, Siri Camee van Keulen

Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transduction pathways, which is a well-known target for drug development. AC is regulated by activated stimulatory (Gαs) and inhibitory (Gαi) G proteins in the cy ...

Public Library of Science2017

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz, Alessandra Piersigilli, Julie Deuquet Ariosa, Jérôme Bürgi

Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and ...

Springer Nature2017

Effect of N-Terminal Myristoylation on the Active Conformation of Gα

Ursula Röthlisberger, Siri Camee van Keulen

G proteins are part of the G-protein-coupled receptor (GPCR) signal transduction cascade in which they transfer a signal from the membrane-embedded GPCR to other proteins in the cell. In the case of the inhibitory G-protein heterotrimer, permanent N-termin ...

2017

Machine learning unifies the modeling of materials and molecules

Michele Ceriotti, Sandip De

Determining the stability ofmolecules and condensed phases is the cornerstone of atomisticmodeling, underpinning our understanding of chemical andmaterials properties and transformations. We show that amachine-learningmodel, based on a local description of ...

Amer Assoc Advancement Science2017

CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation

Anita Nasrallah, Caterina Collodet, Judit Castillo Armengol

The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embry ...

Cell Press2017

How Rhodopsin Tunes the Equilibrium between Protonated and Deprotonated Forms of the Retinal Chromophore

Ursula Röthlisberger, Siri Camee van Keulen, Alicia Solano

Rhodopsin is a photoactive G-protein-coupled receptor (GPCR) that converts dim light into a signal for the brain, leading to eyesight. Full activation of this GPCR is achieved after passing through several steps of the protein's photoactivation pathway. Ke ...

2017

Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells

Diego Chiappe

Lysine acetylation is a widespread posttranslational modification affecting many biological pathways. Recent studies indicate that acetylated lysine residues mainly exhibit low acetylation occupancy, but challenges in sample preparation and analysis make i ...

Amer Soc Biochemistry Molecular Biology Inc2017

AMPK alpha 1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Lin Yang, Kei Sakamoto, Caterina Collodet, Laurent Bultot

Control of stem cell fate to either enter terminal differentiation versus returning to quiescence (self-renewal) is crucial for tissue repair. Here, we showed that AMP-activated protein kinase (AMPK), the master metabolic regulator of the cell, controls mu ...

Wiley2017

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Récepteur couplé aux protéines G

Computational Investigation of Intracellular Signalling Cascades

Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

Effect of N-Terminal Myristoylation on the Active Conformation of Gα

Machine learning unifies the modeling of materials and molecules

CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

How Rhodopsin Tunes the Equilibrium between Protonated and Deprotonated Forms of the Retinal Chromophore

Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells

AMPK alpha 1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Graph Chatbot

Chattez avec Graph Search

Effect of N-Terminal Myristoylation on the Active Conformation of Gα

Machine learning unifies the modeling of materials and molecules

AMPK alpha 1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gαi1

Novel systems biology approaches for design and analysis of palmitoylation networks reveal its regulatory effects on protein stability, activity and localization

Lysine acetylation stoichiometry and proteomics analyses reveal pathways regulated by sirtuin 1 in human cells

Computational Investigation of Intracellular Signalling Cascades

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome

How Rhodopsin Tunes the Equilibrium between Protonated and Deprotonated Forms of the Retinal Chromophore

CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation